Morphologic and immunopathologic findings in myasthenia gravis and in congenital myasthenic syndromes

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

Overwhelming evidence now supports Simpson's concept, originally proposed in 1960, that acquired myasthenia gravis (MG) is an autoimmune disease in which antibodies are directed against the nicotine postsynaptic acetylcholine receptor (AChR).1 An autoimmune pathogenesis of acquired MG implies that those myasthenic syndromes which occur in a congenital and familial setting may have a different, non-autoimmune basis. This paper focuses on ultrastructural, immunoelectron microscopic and cytochemical aspects of acquired autoimmune MG and some recently recognised congenital myasthenic syndromes.

Original languageEnglish (US)
Pages (from-to)577-589
Number of pages13
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume43
Issue number7
DOIs
StatePublished - Jan 1 1980

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology
  • Psychiatry and Mental health

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