Monoclonal Gammopathy of Undetermined Significance and Smoldering Multiple Myeloma

Robert A. Kyle; Jesus F. San-Miguel; Maria Victoria Mateos; S. Vincent Rajkumar

doi:10.1016/j.hoc.2014.06.005

Monoclonal Gammopathy of Undetermined Significance and Smoldering Multiple Myeloma

Robert A. Kyle, Jesus F. San-Miguel, Maria Victoria Mateos, S. Vincent Rajkumar

Hematology

Research output: Contribution to journal › Review article › peer-review

26 Scopus citations

Abstract

Monoclonal gammopathy of undetermined significance (MGUS) is characterized by an M spike less than 3g/dL and a bone marrow containing fewer than 10% plasma cells without evidence of CRAB (hypercalcemia, renal insufficiency, anemia, or bone lesions). Light chain MGUS has an abnormal free light chain (FLC) ratio, increased level of the involved FLC, no monoclonal heavy chain, and fewer than 10% monoclonal plasma cells in the bone marrow. Smoldering multiple myeloma has an M protein of at least 3g/dL and/or at least 10% monoclonal plasma cells in the bone marrow without CRAB features.

Original language	English (US)
Pages (from-to)	775-790
Number of pages	16
Journal	Hematology/Oncology Clinics of North America
Volume	28
Issue number	5
DOIs	https://doi.org/10.1016/j.hoc.2014.06.005
State	Published - Oct 1 2014

Keywords

Light chain monoclonal gammopathy of undetermined significance
Monoclonal gammopathy of undetermined significance
Multiple myeloma
Smoldering multiple myeloma

ASJC Scopus subject areas

Hematology
Oncology

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10.1016/j.hoc.2014.06.005

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title = "Monoclonal Gammopathy of Undetermined Significance and Smoldering Multiple Myeloma",

abstract = "Monoclonal gammopathy of undetermined significance (MGUS) is characterized by an M spike less than 3g/dL and a bone marrow containing fewer than 10% plasma cells without evidence of CRAB (hypercalcemia, renal insufficiency, anemia, or bone lesions). Light chain MGUS has an abnormal free light chain (FLC) ratio, increased level of the involved FLC, no monoclonal heavy chain, and fewer than 10% monoclonal plasma cells in the bone marrow. Smoldering multiple myeloma has an M protein of at least 3g/dL and/or at least 10% monoclonal plasma cells in the bone marrow without CRAB features.",

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AU - San-Miguel, Jesus F.

AU - Mateos, Maria Victoria

AU - Rajkumar, S. Vincent

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AB - Monoclonal gammopathy of undetermined significance (MGUS) is characterized by an M spike less than 3g/dL and a bone marrow containing fewer than 10% plasma cells without evidence of CRAB (hypercalcemia, renal insufficiency, anemia, or bone lesions). Light chain MGUS has an abnormal free light chain (FLC) ratio, increased level of the involved FLC, no monoclonal heavy chain, and fewer than 10% monoclonal plasma cells in the bone marrow. Smoldering multiple myeloma has an M protein of at least 3g/dL and/or at least 10% monoclonal plasma cells in the bone marrow without CRAB features.

KW - Light chain monoclonal gammopathy of undetermined significance

KW - Monoclonal gammopathy of undetermined significance

KW - Multiple myeloma

KW - Smoldering multiple myeloma

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Monoclonal Gammopathy of Undetermined Significance and Smoldering Multiple Myeloma

Abstract

Keywords

ASJC Scopus subject areas

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