Monoclonal Gammopathy of Undetermined Significance and Smoldering Multiple Myeloma

Robert A. Kyle, Jesus F. San-Miguel, Maria Victoria Mateos, S. Vincent Rajkumar

Research output: Contribution to journalReview article

23 Scopus citations

Abstract

Monoclonal gammopathy of undetermined significance (MGUS) is characterized by an M spike less than 3g/dL and a bone marrow containing fewer than 10% plasma cells without evidence of CRAB (hypercalcemia, renal insufficiency, anemia, or bone lesions). Light chain MGUS has an abnormal free light chain (FLC) ratio, increased level of the involved FLC, no monoclonal heavy chain, and fewer than 10% monoclonal plasma cells in the bone marrow. Smoldering multiple myeloma has an M protein of at least 3g/dL and/or at least 10% monoclonal plasma cells in the bone marrow without CRAB features.

Original languageEnglish (US)
Pages (from-to)775-790
Number of pages16
JournalHematology/Oncology Clinics of North America
Volume28
Issue number5
DOIs
StatePublished - Oct 1 2014

Keywords

  • Light chain monoclonal gammopathy of undetermined significance
  • Monoclonal gammopathy of undetermined significance
  • Multiple myeloma
  • Smoldering multiple myeloma

ASJC Scopus subject areas

  • Hematology
  • Oncology

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