Monoclonal gammopathy of undetermined significance

Robert A. Kyle; S. Vincent Rajkumar

doi:10.1007/978-1-4614-3764-2_38

Monoclonal gammopathy of undetermined significance

Robert A. Kyle, S. Vincent Rajkumar

Hematology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

The term monoclonal gammopathy of undetermined significance (MGUS) denotes the presence of a monoclonal protein (M protein) in persons without evidence of multiple myeloma (MM), Waldenström's macroglobulinemia (WM), AL amyloidosis (AL), or other related diseases. MGUS is characterized by a serum M-protein concentration of less than 3.0 g/dL; less than 10 % clonal plasma cells in the bone marrow; and the absence of end-organ damage (CRAB-hypercalcemia, renal insufficiency, anemia, and bone lesions) related to the plasma cell proliferative disorder [1-4].

Original language	English (US)
Title of host publication	Neoplastic Diseases of the Blood
Publisher	Springer New York
Pages	751-785
Number of pages	35
ISBN (Electronic)	9781461437642
ISBN (Print)	1461437636, 9781461437635
DOIs	https://doi.org/10.1007/978-1-4614-3764-2_38
State	Published - Nov 1 2013

Keywords

Long-term outcome of MGUS
MGUS association with other diseases
MGUS prevalence
Risk factors for progression of MGUS
Variants of MGUS

ASJC Scopus subject areas

Medicine(all)

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10.1007/978-1-4614-3764-2_38

Cite this

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abstract = "The term monoclonal gammopathy of undetermined significance (MGUS) denotes the presence of a monoclonal protein (M protein) in persons without evidence of multiple myeloma (MM), Waldenstr{\"o}m's macroglobulinemia (WM), AL amyloidosis (AL), or other related diseases. MGUS is characterized by a serum M-protein concentration of less than 3.0 g/dL; less than 10 % clonal plasma cells in the bone marrow; and the absence of end-organ damage (CRAB-hypercalcemia, renal insufficiency, anemia, and bone lesions) related to the plasma cell proliferative disorder [1-4].",

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AB - The term monoclonal gammopathy of undetermined significance (MGUS) denotes the presence of a monoclonal protein (M protein) in persons without evidence of multiple myeloma (MM), Waldenström's macroglobulinemia (WM), AL amyloidosis (AL), or other related diseases. MGUS is characterized by a serum M-protein concentration of less than 3.0 g/dL; less than 10 % clonal plasma cells in the bone marrow; and the absence of end-organ damage (CRAB-hypercalcemia, renal insufficiency, anemia, and bone lesions) related to the plasma cell proliferative disorder [1-4].

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KW - MGUS association with other diseases

KW - MGUS prevalence

KW - Risk factors for progression of MGUS

KW - Variants of MGUS

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ER -

Monoclonal gammopathy of undetermined significance

Abstract

Keywords

ASJC Scopus subject areas

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