Monoclonal gammopathy-associated pure red cell aplasia

Neha Korde, Yong Zhang, Kelsey Loeliger, Andrea Poon, Olga Simakova, Adriana Zingone, Rene Costello, Richard Childs, Pierre Noel, Samuel Silver, Mary Kwok, Clifton Mo, Neal Young, Ola Landgren, Elaine Sloand, Irina Maric

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Pure red cell aplasia (PRCA) is a rare disorder characterized by inhibition of erythroid precursors in the bone marrow and normochromic, normocytic anaemia with reticulocytopenia. Among 51 PRCA patients, we identified 12 (24%) patients having monoclonal gammopathy, monoclonal gammopathy of undetermined significance or smouldering multiple myeloma, with presence of monoclonal protein or abnormal serum free light chains and atypical bone marrow features of clonal plasmacytosis, hypercellularity and fibrosis. Thus far, three patients treated with anti-myeloma based therapeutics have responded with reticulocyte recovery and clinical transfusion independence, suggesting plasma cells play a key role in the pathogenesis of this specific monoclonal gammopathy-associated PRCA.

Original languageEnglish (US)
Pages (from-to)876-883
Number of pages8
JournalBritish journal of haematology
Volume173
Issue number6
DOIs
StatePublished - Jun 1 2016

Keywords

  • anaemia
  • monoclonal gammopathy of undetermined significance
  • myeloma
  • plasmacytosis
  • pure red cell aplasia

ASJC Scopus subject areas

  • Hematology

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  • Cite this

    Korde, N., Zhang, Y., Loeliger, K., Poon, A., Simakova, O., Zingone, A., Costello, R., Childs, R., Noel, P., Silver, S., Kwok, M., Mo, C., Young, N., Landgren, O., Sloand, E., & Maric, I. (2016). Monoclonal gammopathy-associated pure red cell aplasia. British journal of haematology, 173(6), 876-883. https://doi.org/10.1111/bjh.14012