Molecular Profiling and Research of Therapeutic Targets

Sumera Rizvi; Gregory J. Gores

doi:10.1159/000375347

Molecular Profiling and Research of Therapeutic Targets

Sumera Rizvi, Gregory J. Gores

Gastroenterology and Hepatology

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The heterogeneous nature of hepatocellular carcinoma (HCC) poses a challenge to effective therapy. Significant strides have been made in molecular profiling. Telomerase promoter mutations are now known to represent early events in linear carcinogenesis. However, the translation of these advances into clinical practice has been limited. Although further work is needed to extrapolate genetic information to patient care, progress has been made in using genetics and stratification for HCC therapy. Targeted therapies for patients with c-MET overexpression, VEGF-A amplification and Wnt β-catenin-driven tumors offer promise.

Original language	English (US)
Pages (from-to)	586-589
Number of pages	4
Journal	Digestive Diseases
Volume	33
Issue number	4
DOIs	https://doi.org/10.1159/000375347
State	Published - Jul 22 2015

Keywords

Hepatocellular carcinoma
Immune modulation
Synthetic lethality

ASJC Scopus subject areas

Gastroenterology

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10.1159/000375347

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title = "Molecular Profiling and Research of Therapeutic Targets",

abstract = "The heterogeneous nature of hepatocellular carcinoma (HCC) poses a challenge to effective therapy. Significant strides have been made in molecular profiling. Telomerase promoter mutations are now known to represent early events in linear carcinogenesis. However, the translation of these advances into clinical practice has been limited. Although further work is needed to extrapolate genetic information to patient care, progress has been made in using genetics and stratification for HCC therapy. Targeted therapies for patients with c-MET overexpression, VEGF-A amplification and Wnt β-catenin-driven tumors offer promise.",

keywords = "Hepatocellular carcinoma, Immune modulation, Synthetic lethality",

author = "Sumera Rizvi and Gores, {Gregory J.}",

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year = "2015",

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AB - The heterogeneous nature of hepatocellular carcinoma (HCC) poses a challenge to effective therapy. Significant strides have been made in molecular profiling. Telomerase promoter mutations are now known to represent early events in linear carcinogenesis. However, the translation of these advances into clinical practice has been limited. Although further work is needed to extrapolate genetic information to patient care, progress has been made in using genetics and stratification for HCC therapy. Targeted therapies for patients with c-MET overexpression, VEGF-A amplification and Wnt β-catenin-driven tumors offer promise.

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KW - Immune modulation

KW - Synthetic lethality

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Molecular Profiling and Research of Therapeutic Targets

Abstract

Keywords

ASJC Scopus subject areas

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