Abstract
Numerous techniques have been used to elucidate the structural basis for interaction of cholecystokinin (CCK)-related peptides with their hormone-binding receptor, the CCK-A receptor (CCK-AR), including structure-activity relationship studies, site-directed mutagenesis, photoaffinity-labeling, and solution NMR analysis of both CCK peptide ligands and peptide fragments derived from the CCK-A receptor. Different structural models have been developed for the peptide-receptor complexes using various subsets of the available experimental data (Giragossian & Mierke 2001; Ding et al. 2002; Escrieut et al. 2002). Here, we review details of the various models and evaluate the impact of selected experimental data sets on model development.
Original language | English (US) |
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Pages (from-to) | 290-296 |
Number of pages | 7 |
Journal | Pharmacology and Toxicology |
Volume | 91 |
Issue number | 6 |
DOIs | |
State | Published - Dec 1 2002 |
ASJC Scopus subject areas
- Toxicology
- Pharmacology
- Health, Toxicology and Mutagenesis