Molecular models for cholecystokinin-A receptor

Eric S. Dawson, Randel M. Henne, Laurence J. Miller, Terry P. Lybrand

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Numerous techniques have been used to elucidate the structural basis for interaction of cholecystokinin (CCK)-related peptides with their hormone-binding receptor, the CCK-A receptor (CCK-AR), including structure-activity relationship studies, site-directed mutagenesis, photoaffinity-labeling, and solution NMR analysis of both CCK peptide ligands and peptide fragments derived from the CCK-A receptor. Different structural models have been developed for the peptide-receptor complexes using various subsets of the available experimental data (Giragossian & Mierke 2001; Ding et al. 2002; Escrieut et al. 2002). Here, we review details of the various models and evaluate the impact of selected experimental data sets on model development.

Original languageEnglish (US)
Pages (from-to)290-296
Number of pages7
JournalPharmacology and Toxicology
Volume91
Issue number6
DOIs
StatePublished - Dec 1 2002

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ASJC Scopus subject areas

  • Toxicology
  • Pharmacology
  • Health, Toxicology and Mutagenesis

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