Molecular determinants of metaplastic and neoplastic transformation in the esophageal epithelium

Abhayjit Singh, Cathrine Demars, Navtej Singh Buttar

Research output: Contribution to journalArticle

Abstract

A metaplastic change where normal squamous mucosa of the esophagus is replaced by columnar mucosa is considered an adaptive process to withstand the chronic gastroesophageal reflux injury. However, this phenotypic switch in the esophageal mucosa is associated with an increased propensity to undergo neoplastic transformation. In this chapter, we review the molecular alterations that are relevant to metaplastic and neoplastic transformations in the esophagus and also discuss the mechanisms that could potentially contribute to this transformation.

Original languageEnglish (US)
Pages (from-to)63-92
Number of pages30
JournalProgress in Molecular Biology and Translational Science
Volume96
Issue numberC
DOIs
StatePublished - 2010

Fingerprint

Epithelium
Gastroesophageal Reflux
Esophagus
Mucous Membrane
Wounds and Injuries
Esophageal Mucosa

Keywords

  • Adenocarcinoma
  • Barrett's metaplasia
  • Esophageal stem cell
  • Esophagus
  • Molecular pathways
  • Signaling pathways
  • Transcriptional regulation

ASJC Scopus subject areas

  • Molecular Biology
  • Molecular Medicine

Cite this

Molecular determinants of metaplastic and neoplastic transformation in the esophageal epithelium. / Singh, Abhayjit; Demars, Cathrine; Buttar, Navtej Singh.

In: Progress in Molecular Biology and Translational Science, Vol. 96, No. C, 2010, p. 63-92.

Research output: Contribution to journalArticle

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