Molecular determinants of metaplastic and neoplastic transformation in the esophageal epithelium

Abhayjit Singh, Cathrine Demars, Navtej S. Buttar

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

A metaplastic change where normal squamous mucosa of the esophagus is replaced by columnar mucosa is considered an adaptive process to withstand the chronic gastroesophageal reflux injury. However, this phenotypic switch in the esophageal mucosa is associated with an increased propensity to undergo neoplastic transformation. In this chapter, we review the molecular alterations that are relevant to metaplastic and neoplastic transformations in the esophagus and also discuss the mechanisms that could potentially contribute to this transformation.

Original languageEnglish (US)
Title of host publicationProgress in Molecular Biology and Translational Science
PublisherElsevier B.V.
Pages63-92
Number of pages30
EditionC
DOIs
StatePublished - Jan 1 2010

Publication series

NameProgress in Molecular Biology and Translational Science
NumberC
Volume96
ISSN (Print)1877-1173

Keywords

  • Adenocarcinoma
  • Barrett's metaplasia
  • Esophageal stem cell
  • Esophagus
  • Molecular pathways
  • Signaling pathways
  • Transcriptional regulation

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

Fingerprint Dive into the research topics of 'Molecular determinants of metaplastic and neoplastic transformation in the esophageal epithelium'. Together they form a unique fingerprint.

  • Cite this

    Singh, A., Demars, C., & Buttar, N. S. (2010). Molecular determinants of metaplastic and neoplastic transformation in the esophageal epithelium. In Progress in Molecular Biology and Translational Science (C ed., pp. 63-92). (Progress in Molecular Biology and Translational Science; Vol. 96, No. C). Elsevier B.V.. https://doi.org/10.1016/B978-0-12-381280-3.00003-8