Models of renovascular disease

Xin Zhang, Alfonso Eirin

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Renal artery stenosis, often associated with multiple atherosclerotic risk factors, is a common cause of secondary hypertension, exacerbates cardiovascular disease, and leads to chronic renal failure. Therefore, it is critically important to elucidate the mechanisms responsible for disease progression and develop effective therapeutic strategies to treat these patients. Animal models have been extensively used as an experimental platform to mimic many features of human renovascular disease, and provide valuable information to probe its pathophysiology and downstream kidney injury. This chapter summarizes different methods used to develop and evaluate animal models of renovascular disease, often applying the Goldblatt two-kidney one-clip hypertension (2K1C) model in murine to large animal models, such as swine and canine. Finally, this chapter will examine different methods to monitor pathophysiological changes in renovascular hypertensive animal models and the use of therapeutic interventions, such as renal revascularization.

Original languageEnglish (US)
Title of host publicationRenal Vascular Disease
PublisherSpringer-Verlag London Ltd
Pages105-116
Number of pages12
Volume9781447128106
ISBN (Electronic)9781447128106
ISBN (Print)1447128095, 9781447128090
DOIs
StatePublished - Dec 1 2014

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Keywords

  • 2K1C
  • Animal models
  • Atherosclerosis
  • Genetic engineering models
  • Hypertension
  • Renal artery stenosis
  • Renin-angiotensin system
  • Renovascular disease

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Zhang, X., & Eirin, A. (2014). Models of renovascular disease. In Renal Vascular Disease (Vol. 9781447128106, pp. 105-116). Springer-Verlag London Ltd. https://doi.org/10.1007/978-1-4471-2810-6_6