Mitotic kinase cascades orchestrating timely disjunction and movement of centrosomes maintain chromosomal stability and prevent cancer

Janine H. van Ree, Hyun Ja Nam, Jan Van Deursen

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Centrosomes are microtubule-organizing centers that duplicate in S phase to form bipolar spindles that separate duplicated chromosomes faithfully into two daughter cells during cell division. Recent studies show that proper timing of centrosome dynamics, the disjunction and movement of centrosomes, is tightly linked to spindle symmetry, correct microtubule-kinetochore attachment, and chromosome segregation. Here, we review mechanisms that regulate centrosome dynamics, with emphasis on the roles of key mitotic kinases in the proper timing of centrosome dynamics and how aberrancies in these processes may cause chromosomal instability and cancer.

Original languageEnglish (US)
Pages (from-to)67-76
Number of pages10
JournalChromosome Research
Volume24
Issue number1
DOIs
StatePublished - Jan 1 2016

Fingerprint

Centrosome
Chromosomal Instability
Phosphotransferases
Neoplasms
Microtubule-Organizing Center
Kinetochores
Chromosome Segregation
S Phase
Microtubules
Cell Division
Chromosomes

Keywords

  • Aneuploidy
  • Cancer
  • Centrosome disjunction
  • Centrosome movement
  • Chromosomal instability
  • Chromosome lagging
  • Mitotic kinases
  • Spindle assembly

ASJC Scopus subject areas

  • Genetics

Cite this

Mitotic kinase cascades orchestrating timely disjunction and movement of centrosomes maintain chromosomal stability and prevent cancer. / van Ree, Janine H.; Nam, Hyun Ja; Van Deursen, Jan.

In: Chromosome Research, Vol. 24, No. 1, 01.01.2016, p. 67-76.

Research output: Contribution to journalArticle

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