Mitotic kinase cascades orchestrating timely disjunction and movement of centrosomes maintain chromosomal stability and prevent cancer

Janine H. van Ree, Hyun Ja Nam, Jan M. van Deursen

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations

Abstract

Centrosomes are microtubule-organizing centers that duplicate in S phase to form bipolar spindles that separate duplicated chromosomes faithfully into two daughter cells during cell division. Recent studies show that proper timing of centrosome dynamics, the disjunction and movement of centrosomes, is tightly linked to spindle symmetry, correct microtubule-kinetochore attachment, and chromosome segregation. Here, we review mechanisms that regulate centrosome dynamics, with emphasis on the roles of key mitotic kinases in the proper timing of centrosome dynamics and how aberrancies in these processes may cause chromosomal instability and cancer.

Original languageEnglish (US)
Pages (from-to)67-76
Number of pages10
JournalChromosome Research
Volume24
Issue number1
DOIs
StatePublished - Jan 1 2016

Keywords

  • Aneuploidy
  • Cancer
  • Centrosome disjunction
  • Centrosome movement
  • Chromosomal instability
  • Chromosome lagging
  • Mitotic kinases
  • Spindle assembly

ASJC Scopus subject areas

  • Genetics

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