Mitochondrial DNA and gastrointestinal motor and sensory functions in health and functional gastrointestinal disorders

Michael Camilleri, Paula Carlson, Alan R. Zinsmeister, Sanna McKinzie, Irene Busciglio, Duane Burton, Essam A. Zaki, Richard G. Boles

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Nerve, muscle, and inflammatory cells involved in gastrointestinal (GI) function have high-energy requirements and are affected in mitochondrial disorders. Familial aggregation of irritable bowel syndrome (IBS) frequently involves mothers and their children. Since mitochondrial DNA (mtDNA) is maternally inherited, mtDNA single nucleotide polymorphisms (SNPs) could confer risk to the development of IBS. The mtDNA SNPs, 16519C>T and 3010G>A, are associated with migraine and childhood cyclic vomiting syndrome. Our hypothesis is that these mtDNA SNPs are associated with functional GI disorders (FGIDs) and GI functions. The mt genome was first tested for the 7028C polymorphism (defining haplogroup H) in 699 patients or controls, and those with 7028C were further genotyped at 16519 and 3010. Phenotypes were based on symptoms (validated questionnaires and criteria) and GI physiology using validated motor and sensory studies. Constipation-predominant IBS and alternating constipation and diarrhea IBS are less prevalent in individuals with the 7028C mtDNA polymorphism than in individuals with 7028T. Conversely, 7028C is associated with higher maximum tolerated volume (lower satiation) compared with 7028T. Among those with 7028C, nonspecific abdominal pain (chronic abdominal pain or dyspepsia) was significantly associated with 3010A compared with 3010G (odds ratio 3.3, P = 0.02), and slower gastric emptying was statistically associated with 3010G. There were no significant associations of mtDNA genotypes tested and stomach volumes, small bowel or colonic transit, rectal compliance, and motor or sensory functions. Thus variation in mtDNA may be associated with satiation, gastric emptying, and possibly pain; further studies of mtDNA in appetite regulation and larger numbers of patients with FGIDs are warranted.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
Volume296
Issue number3
DOIs
StatePublished - Mar 2009

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Gastrointestinal Diseases
Mitochondrial DNA
Irritable Bowel Syndrome
Health
Satiation
Single Nucleotide Polymorphism
Gastric Emptying
Constipation
Abdominal Pain
Appetite Regulation
Mitochondrial Diseases
Dyspepsia
Migraine Disorders
Chronic Pain
Muscle Cells
Compliance
Diarrhea
Stomach
Odds Ratio
Genotype

Keywords

  • 16519T
  • 3010A
  • 7028C
  • Accommodation
  • Constipation
  • Dyspepsia
  • Gastric emptying
  • Genotype
  • Haplogroup H
  • Irritable bowel syndrome
  • Nonspecific abdominal pain
  • Satiation
  • Somatic symptoms

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology
  • Hepatology
  • Physiology (medical)

Cite this

Mitochondrial DNA and gastrointestinal motor and sensory functions in health and functional gastrointestinal disorders. / Camilleri, Michael; Carlson, Paula; Zinsmeister, Alan R.; McKinzie, Sanna; Busciglio, Irene; Burton, Duane; Zaki, Essam A.; Boles, Richard G.

In: American Journal of Physiology - Gastrointestinal and Liver Physiology, Vol. 296, No. 3, 03.2009.

Research output: Contribution to journalArticle

Camilleri, Michael ; Carlson, Paula ; Zinsmeister, Alan R. ; McKinzie, Sanna ; Busciglio, Irene ; Burton, Duane ; Zaki, Essam A. ; Boles, Richard G. / Mitochondrial DNA and gastrointestinal motor and sensory functions in health and functional gastrointestinal disorders. In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 2009 ; Vol. 296, No. 3.
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