Mitochondrial DNA alterations and reduced mitochondrial function in aging

Research output: Contribution to journalArticle

53 Scopus citations

Abstract

Oxidative damage to mitochondrial DNA increases with aging. This damage has the potential to affect mitochondrial DNA replication and transcription which could alter the abundance or functionality of mitochondrial proteins. This review describes mitochondrial DNA alterations and changes in mitochondrial function that occur with aging. Age-related alterations in mitochondrial DNA as a possible contributor to the reduction in mitochondrial function are discussed.

Original languageEnglish (US)
Pages (from-to)451-462
Number of pages12
JournalMechanisms of Ageing and Development
Volume131
Issue number7-8
DOIs
StatePublished - Jul 1 2010

Keywords

  • Aging
  • Mitochondria
  • Mitochondrial DNA

ASJC Scopus subject areas

  • Aging
  • Developmental Biology

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