Mitochondrial DNA alterations and reduced mitochondrial function in aging

Sadie L. Hebert; Ian R. Lanza; K. Sreekumaran Nair

doi:10.1016/j.mad.2010.03.007

Mitochondrial DNA alterations and reduced mitochondrial function in aging

Sadie L. Hebert, Ian R. Lanza, K. Sreekumaran Nair

Endocrinology, Diabetes, Metabolism, and Nutrition

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Abstract

Oxidative damage to mitochondrial DNA increases with aging. This damage has the potential to affect mitochondrial DNA replication and transcription which could alter the abundance or functionality of mitochondrial proteins. This review describes mitochondrial DNA alterations and changes in mitochondrial function that occur with aging. Age-related alterations in mitochondrial DNA as a possible contributor to the reduction in mitochondrial function are discussed.

Original language	English (US)
Pages (from-to)	451-462
Number of pages	12
Journal	Mechanisms of Ageing and Development
Volume	131
Issue number	7-8
DOIs	https://doi.org/10.1016/j.mad.2010.03.007
State	Published - Jul 2010

Keywords

Aging
Mitochondria
Mitochondrial DNA

ASJC Scopus subject areas

Aging
Developmental Biology

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10.1016/j.mad.2010.03.007

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title = "Mitochondrial DNA alterations and reduced mitochondrial function in aging",

abstract = "Oxidative damage to mitochondrial DNA increases with aging. This damage has the potential to affect mitochondrial DNA replication and transcription which could alter the abundance or functionality of mitochondrial proteins. This review describes mitochondrial DNA alterations and changes in mitochondrial function that occur with aging. Age-related alterations in mitochondrial DNA as a possible contributor to the reduction in mitochondrial function are discussed.",

keywords = "Aging, Mitochondria, Mitochondrial DNA",

author = "Hebert, {Sadie L.} and Lanza, {Ian R.} and Nair, {K. Sreekumaran}",

year = "2010",

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AU - Hebert, Sadie L.

AU - Lanza, Ian R.

AU - Nair, K. Sreekumaran

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N2 - Oxidative damage to mitochondrial DNA increases with aging. This damage has the potential to affect mitochondrial DNA replication and transcription which could alter the abundance or functionality of mitochondrial proteins. This review describes mitochondrial DNA alterations and changes in mitochondrial function that occur with aging. Age-related alterations in mitochondrial DNA as a possible contributor to the reduction in mitochondrial function are discussed.

AB - Oxidative damage to mitochondrial DNA increases with aging. This damage has the potential to affect mitochondrial DNA replication and transcription which could alter the abundance or functionality of mitochondrial proteins. This review describes mitochondrial DNA alterations and changes in mitochondrial function that occur with aging. Age-related alterations in mitochondrial DNA as a possible contributor to the reduction in mitochondrial function are discussed.

KW - Aging

KW - Mitochondria

KW - Mitochondrial DNA

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ER -

Mitochondrial DNA alterations and reduced mitochondrial function in aging

Abstract

Keywords

ASJC Scopus subject areas

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