Abstract
Insulin-induced hypoglycemia causes somnolence in rhesus monkeys, a phenomenon usually considered an aspecific consequence of neuroglycopenia. Previous observations from our laboratory have raised the possibility that arginine vasopressin (AVP) may also play a role in this decrease in wakefulness. In the present study we tested this hypothesis by inducing hypoglycemia (~ 40 mg/dl) in ovariectomized rhesus monkeys by intravenous administration of insulin in the presence of continuous intracerebroventricular infusions of the V1 receptor antagonist [deamino- Pen1,O-Me-Tyr2,Arg8]-vasopressin (180 μg/60 μl per h) or of its vehicle alone (artificial cerebrospinal fluid, 60 μl/h). Wakefulness was assessed by a scoring system by observers blinded to the experimental protocol. The AVP antagonist significantly attenuated the decrease in wakefulness observed in response to insulin-induced hypoglycemia (p < .03) without increasing blood glucose levels. These and previous findings suggest that the somnolence induced by a moderate degree of hypoglycemia may not entirely be the direct consequence of neuroglycopenia and that AVP may, directly or indirectly, be involved.
Original language | English (US) |
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Pages (from-to) | 497-503 |
Number of pages | 7 |
Journal | Psychoneuroendocrinology |
Volume | 23 |
Issue number | 5 |
DOIs | |
State | Published - Jul 1998 |
Keywords
- Induced hypoglycemia
- Insulin
- Neuroglycopenia
- Rhesus monkey
- Somnolence
- V receptor antagonist
- Vasopressin
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Endocrinology
- Endocrine and Autonomic Systems
- Psychiatry and Mental health
- Biological Psychiatry