Mitigation of the somnolence of insulin-induced hypoglycemia by a vasopressin V1 receptor antagonist in the rhesus monkey

Ming Dao Chen, Tamás Ördög, Ernst Knobil

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1 Scopus citations


Insulin-induced hypoglycemia causes somnolence in rhesus monkeys, a phenomenon usually considered an aspecific consequence of neuroglycopenia. Previous observations from our laboratory have raised the possibility that arginine vasopressin (AVP) may also play a role in this decrease in wakefulness. In the present study we tested this hypothesis by inducing hypoglycemia (~ 40 mg/dl) in ovariectomized rhesus monkeys by intravenous administration of insulin in the presence of continuous intracerebroventricular infusions of the V1 receptor antagonist [deamino- Pen1,O-Me-Tyr2,Arg8]-vasopressin (180 μg/60 μl per h) or of its vehicle alone (artificial cerebrospinal fluid, 60 μl/h). Wakefulness was assessed by a scoring system by observers blinded to the experimental protocol. The AVP antagonist significantly attenuated the decrease in wakefulness observed in response to insulin-induced hypoglycemia (p < .03) without increasing blood glucose levels. These and previous findings suggest that the somnolence induced by a moderate degree of hypoglycemia may not entirely be the direct consequence of neuroglycopenia and that AVP may, directly or indirectly, be involved.

Original languageEnglish (US)
Pages (from-to)497-503
Number of pages7
Issue number5
StatePublished - Jul 1998


  • Induced hypoglycemia
  • Insulin
  • Neuroglycopenia
  • Rhesus monkey
  • Somnolence
  • V receptor antagonist
  • Vasopressin

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Psychiatry and Mental health
  • Biological Psychiatry


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