TY - JOUR
T1 - Minocycline safety and tolerability in huntington disease
AU - Huntington study group
AU - Cha, Jang Ho
AU - Cudkowicz, Merit E.
AU - Gevorkian, Sona
AU - Young, Anne
AU - De Blieck, Elisabeth A.
AU - Kieburtz, Karl
AU - Marshall, Frederick
AU - Oakes, David
AU - Aileen Shinaman, M.
AU - Shoulson, Ira
AU - Zhao, Hongwei
AU - Friedlander, Robert
AU - Walker, Francis
AU - Hunt, Vicki
AU - Martin, Wayne
AU - Wieler, Marguerite
AU - Caviness, John
AU - Bernstein, Susan
AU - Anderson, Karen
AU - Weiner, William
AU - Dustin, Kelly
AU - Rosas, Diana
AU - Skeuse, Colleen
AU - Lausier, Martha
AU - Qureshi, Muhammad M.
AU - Biglan, Kevin
AU - Como, Peter
AU - Zimmerman, Carol
AU - Paulson, Henry
AU - Niehus, Kathryn
AU - Jennings, Danna
AU - Caplan, Karen
AU - Macdonald, Marcy
AU - Bean, Stephen
AU - De Blieck, Elisabeth A.
AU - Marshall, Frederick
AU - Orme, Constance
AU - Preston, Larry
AU - Weaver, Christine
AU - Winebrenner, Tina
AU - Bourgeois, Keith
AU - Watts, Arthur
AU - Zhao, Hongwei
N1 - Publisher Copyright:
© 2004 by AAN Enterprises, Inc.
PY - 2004/8/10
Y1 - 2004/8/10
N2 - Minocycline is an antibiotic with anti-inflammatory and antiapoptotic properties that prolongs survival in a transgenic Huntington disease (HD) mouse model. In a double-blind, randomized, placebo-controlled study of minocycline in 60 HD patients, the authors determined that over 8 weeks, minocycline at 100 and 200 mg/day was well tolerated and safe in HD patients. Tolerability and adverse event frequency were similar between treatment and placebo groups.
AB - Minocycline is an antibiotic with anti-inflammatory and antiapoptotic properties that prolongs survival in a transgenic Huntington disease (HD) mouse model. In a double-blind, randomized, placebo-controlled study of minocycline in 60 HD patients, the authors determined that over 8 weeks, minocycline at 100 and 200 mg/day was well tolerated and safe in HD patients. Tolerability and adverse event frequency were similar between treatment and placebo groups.
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U2 - 10.1212/01.WNL.0000133403.30559.FF
DO - 10.1212/01.WNL.0000133403.30559.FF
M3 - Article
C2 - 15304592
AN - SCOPUS:3543092682
SN - 0028-3878
VL - 63
SP - 547
EP - 549
JO - Neurology
JF - Neurology
IS - 3
ER -