TY - JOUR
T1 - Minimally Invasive and Regenerative Therapeutics
AU - Ashammakhi, Nureddin
AU - Ahadian, Samad
AU - Darabi, Mohammad Ali
AU - El Tahchi, Mario
AU - Lee, Junmin
AU - Suthiwanich, Kasinan
AU - Sheikhi, Amir
AU - Dokmeci, Mehmet R.
AU - Oklu, Rahmi
AU - Khademhosseini, Ali
N1 - Funding Information:
This article is part of the Advanced Materials Hall of Fame article series, which recognizes the excellent contributions of leading researchers to the field of materials science. N.A. and S.A. contributed equally to this work. The authors acknowledge funding from the National Institutes of Health (Grant Nos. EB021857, AR066193, AR057837, CA214411, HL137193, EB024403, EB023052, EB022403, and EB021857) and Air Force Office of Sponsored Research under Award No. FA9550-15-1-0273. A.S. would like to acknowledge the financial support from the Canadian Institutes of Health Research (CIHR) through a postdoctoral fellowship. The authors thank Mohammed Xohdy for drawing Figure and parts of Figure and 10 and also Outman Akouissi for drawing Figure.
Funding Information:
This article is part of the Advanced Materials Hall of Fame article series, which recognizes the excellent contributions of leading researchers to the field of materials science. N.A. and S.A. contributed equally to this work. The authors acknowledge funding from the National Institutes of Health (Grant Nos. EB021857, AR066193, AR057837, CA214411, HL137193, EB024403, EB023052, EB022403, and EB021857) and Air Force Office of Sponsored Research under Award No. FA9550-15-1-0273. A.S. would like to acknowledge the financial support from the Canadian Institutes of Health Research (CIHR) through a postdoctoral fellowship. The authors thank Mohammed Xohdy for drawing Figure 2 and parts of Figure 5 and 10 and also Outman Akouissi for drawing Figure 6.
Publisher Copyright:
© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2019/1/4
Y1 - 2019/1/4
N2 - Advances in biomaterial synthesis and fabrication, stem cell biology, bioimaging, microsurgery procedures, and microscale technologies have made minimally invasive therapeutics a viable tool in regenerative medicine. Therapeutics, herein defined as cells, biomaterials, biomolecules, and their combinations, can be delivered in a minimally invasive way to regenerate different tissues in the body, such as bone, cartilage, pancreas, cardiac, skeletal muscle, liver, skin, and neural tissues. Sophisticated methods of tracking, sensing, and stimulation of therapeutics in vivo using nano-biomaterials and soft bioelectronic devices provide great opportunities to further develop minimally invasive and regenerative therapeutics (MIRET). In general, minimally invasive delivery methods offer high yield with low risk of complications and reduced costs compared to conventional delivery methods. Here, minimally invasive approaches for delivering regenerative therapeutics into the body are reviewed. The use of MIRET to treat different tissues and organs is described. Although some clinical trials have been performed using MIRET, it is hoped that such therapeutics find wider applications to treat patients. Finally, some future perspective and challenges for this emerging field are highlighted.
AB - Advances in biomaterial synthesis and fabrication, stem cell biology, bioimaging, microsurgery procedures, and microscale technologies have made minimally invasive therapeutics a viable tool in regenerative medicine. Therapeutics, herein defined as cells, biomaterials, biomolecules, and their combinations, can be delivered in a minimally invasive way to regenerate different tissues in the body, such as bone, cartilage, pancreas, cardiac, skeletal muscle, liver, skin, and neural tissues. Sophisticated methods of tracking, sensing, and stimulation of therapeutics in vivo using nano-biomaterials and soft bioelectronic devices provide great opportunities to further develop minimally invasive and regenerative therapeutics (MIRET). In general, minimally invasive delivery methods offer high yield with low risk of complications and reduced costs compared to conventional delivery methods. Here, minimally invasive approaches for delivering regenerative therapeutics into the body are reviewed. The use of MIRET to treat different tissues and organs is described. Although some clinical trials have been performed using MIRET, it is hoped that such therapeutics find wider applications to treat patients. Finally, some future perspective and challenges for this emerging field are highlighted.
KW - biomaterials
KW - biomolecules
KW - delivery
KW - minimally invasive
KW - scaffolds
KW - tissue regeneration
UR - http://www.scopus.com/inward/record.url?scp=85058820883&partnerID=8YFLogxK
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U2 - 10.1002/adma.201804041
DO - 10.1002/adma.201804041
M3 - Review article
C2 - 30565732
AN - SCOPUS:85058820883
SN - 0935-9648
VL - 31
JO - Advanced Materials
JF - Advanced Materials
IS - 1
M1 - 1804041
ER -