Military risk factors for Alzheimer's disease

Michael W. Weiner, Karl E. Friedl, Anthony Pacifico, Julie C. Chapman, Michael S. Jaffee, Deborah M. Little, Geoffrey T. Manley, Ann McKee, Ronald Carl Petersen, Roger K. Pitman, Kristine Yaffe, Henrik Zetterberg, Robert Obana, Lisa J. Bain, Maria C. Carrillo

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD) are signature injuries of the wars in Iraq and Afghanistan and have been linked to an increased risk of Alzheimer's disease (AD) and other dementias. A meeting hosted by the Alzheimer's Association and the Veterans' Health Research Institute (NCIRE) in May 2012 brought together experts from the U.S. military and academic medical centers around the world to discuss current evidence and hypotheses regarding the pathophysiological mechanisms linking TBI, PTSD, and AD. Studies underway in civilian and military populations were highlighted, along with new research initiatives such as a study to extend the Alzheimer's Disease Neuroimaging Initiative (ADNI) to a population of veterans exposed to TBI and PTSD. Greater collaboration and data sharing among diverse research groups is needed to advance an understanding and appropriate interventions in this continuum of military injuries and neurodegenerative disease in the aging veteran.

Original languageEnglish (US)
Pages (from-to)445-451
Number of pages7
JournalAlzheimer's and Dementia
Volume9
Issue number4
DOIs
StatePublished - Jul 2013

Fingerprint

Post-Traumatic Stress Disorders
Alzheimer Disease
Veterans
Veterans Health
Afghanistan
Iraq
Information Dissemination
Wounds and Injuries
Research
Neuroimaging
Neurodegenerative Diseases
Population
Dementia
Traumatic Brain Injury

Keywords

  • Alzheimer's disease
  • Alzheimer's Disease Neuroimaging Initiative
  • Apolipoprotein E e4
  • Beta-amyloid
  • Biomarkers
  • Blast injury
  • Chronic traumatic encephalopathy
  • Military medicine
  • Posttraumatic stress disorder
  • Risk factors
  • Tau
  • Traumatic brain injury
  • Veterans
  • Vietnam

ASJC Scopus subject areas

  • Health Policy
  • Epidemiology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience
  • Developmental Neuroscience
  • Clinical Neurology

Cite this

Weiner, M. W., Friedl, K. E., Pacifico, A., Chapman, J. C., Jaffee, M. S., Little, D. M., ... Carrillo, M. C. (2013). Military risk factors for Alzheimer's disease. Alzheimer's and Dementia, 9(4), 445-451. https://doi.org/10.1016/j.jalz.2013.03.005

Military risk factors for Alzheimer's disease. / Weiner, Michael W.; Friedl, Karl E.; Pacifico, Anthony; Chapman, Julie C.; Jaffee, Michael S.; Little, Deborah M.; Manley, Geoffrey T.; McKee, Ann; Petersen, Ronald Carl; Pitman, Roger K.; Yaffe, Kristine; Zetterberg, Henrik; Obana, Robert; Bain, Lisa J.; Carrillo, Maria C.

In: Alzheimer's and Dementia, Vol. 9, No. 4, 07.2013, p. 445-451.

Research output: Contribution to journalArticle

Weiner, MW, Friedl, KE, Pacifico, A, Chapman, JC, Jaffee, MS, Little, DM, Manley, GT, McKee, A, Petersen, RC, Pitman, RK, Yaffe, K, Zetterberg, H, Obana, R, Bain, LJ & Carrillo, MC 2013, 'Military risk factors for Alzheimer's disease', Alzheimer's and Dementia, vol. 9, no. 4, pp. 445-451. https://doi.org/10.1016/j.jalz.2013.03.005
Weiner MW, Friedl KE, Pacifico A, Chapman JC, Jaffee MS, Little DM et al. Military risk factors for Alzheimer's disease. Alzheimer's and Dementia. 2013 Jul;9(4):445-451. https://doi.org/10.1016/j.jalz.2013.03.005
Weiner, Michael W. ; Friedl, Karl E. ; Pacifico, Anthony ; Chapman, Julie C. ; Jaffee, Michael S. ; Little, Deborah M. ; Manley, Geoffrey T. ; McKee, Ann ; Petersen, Ronald Carl ; Pitman, Roger K. ; Yaffe, Kristine ; Zetterberg, Henrik ; Obana, Robert ; Bain, Lisa J. ; Carrillo, Maria C. / Military risk factors for Alzheimer's disease. In: Alzheimer's and Dementia. 2013 ; Vol. 9, No. 4. pp. 445-451.
@article{aff4153cf9cc4f1291d1ed67b01cb93e,
title = "Military risk factors for Alzheimer's disease",
abstract = "Traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD) are signature injuries of the wars in Iraq and Afghanistan and have been linked to an increased risk of Alzheimer's disease (AD) and other dementias. A meeting hosted by the Alzheimer's Association and the Veterans' Health Research Institute (NCIRE) in May 2012 brought together experts from the U.S. military and academic medical centers around the world to discuss current evidence and hypotheses regarding the pathophysiological mechanisms linking TBI, PTSD, and AD. Studies underway in civilian and military populations were highlighted, along with new research initiatives such as a study to extend the Alzheimer's Disease Neuroimaging Initiative (ADNI) to a population of veterans exposed to TBI and PTSD. Greater collaboration and data sharing among diverse research groups is needed to advance an understanding and appropriate interventions in this continuum of military injuries and neurodegenerative disease in the aging veteran.",
keywords = "Alzheimer's disease, Alzheimer's Disease Neuroimaging Initiative, Apolipoprotein E e4, Beta-amyloid, Biomarkers, Blast injury, Chronic traumatic encephalopathy, Military medicine, Posttraumatic stress disorder, Risk factors, Tau, Traumatic brain injury, Veterans, Vietnam",
author = "Weiner, {Michael W.} and Friedl, {Karl E.} and Anthony Pacifico and Chapman, {Julie C.} and Jaffee, {Michael S.} and Little, {Deborah M.} and Manley, {Geoffrey T.} and Ann McKee and Petersen, {Ronald Carl} and Pitman, {Roger K.} and Kristine Yaffe and Henrik Zetterberg and Robert Obana and Bain, {Lisa J.} and Carrillo, {Maria C.}",
year = "2013",
month = "7",
doi = "10.1016/j.jalz.2013.03.005",
language = "English (US)",
volume = "9",
pages = "445--451",
journal = "Alzheimer's and Dementia",
issn = "1552-5260",
publisher = "Elsevier Inc.",
number = "4",

}

TY - JOUR

T1 - Military risk factors for Alzheimer's disease

AU - Weiner, Michael W.

AU - Friedl, Karl E.

AU - Pacifico, Anthony

AU - Chapman, Julie C.

AU - Jaffee, Michael S.

AU - Little, Deborah M.

AU - Manley, Geoffrey T.

AU - McKee, Ann

AU - Petersen, Ronald Carl

AU - Pitman, Roger K.

AU - Yaffe, Kristine

AU - Zetterberg, Henrik

AU - Obana, Robert

AU - Bain, Lisa J.

AU - Carrillo, Maria C.

PY - 2013/7

Y1 - 2013/7

N2 - Traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD) are signature injuries of the wars in Iraq and Afghanistan and have been linked to an increased risk of Alzheimer's disease (AD) and other dementias. A meeting hosted by the Alzheimer's Association and the Veterans' Health Research Institute (NCIRE) in May 2012 brought together experts from the U.S. military and academic medical centers around the world to discuss current evidence and hypotheses regarding the pathophysiological mechanisms linking TBI, PTSD, and AD. Studies underway in civilian and military populations were highlighted, along with new research initiatives such as a study to extend the Alzheimer's Disease Neuroimaging Initiative (ADNI) to a population of veterans exposed to TBI and PTSD. Greater collaboration and data sharing among diverse research groups is needed to advance an understanding and appropriate interventions in this continuum of military injuries and neurodegenerative disease in the aging veteran.

AB - Traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD) are signature injuries of the wars in Iraq and Afghanistan and have been linked to an increased risk of Alzheimer's disease (AD) and other dementias. A meeting hosted by the Alzheimer's Association and the Veterans' Health Research Institute (NCIRE) in May 2012 brought together experts from the U.S. military and academic medical centers around the world to discuss current evidence and hypotheses regarding the pathophysiological mechanisms linking TBI, PTSD, and AD. Studies underway in civilian and military populations were highlighted, along with new research initiatives such as a study to extend the Alzheimer's Disease Neuroimaging Initiative (ADNI) to a population of veterans exposed to TBI and PTSD. Greater collaboration and data sharing among diverse research groups is needed to advance an understanding and appropriate interventions in this continuum of military injuries and neurodegenerative disease in the aging veteran.

KW - Alzheimer's disease

KW - Alzheimer's Disease Neuroimaging Initiative

KW - Apolipoprotein E e4

KW - Beta-amyloid

KW - Biomarkers

KW - Blast injury

KW - Chronic traumatic encephalopathy

KW - Military medicine

KW - Posttraumatic stress disorder

KW - Risk factors

KW - Tau

KW - Traumatic brain injury

KW - Veterans

KW - Vietnam

UR - http://www.scopus.com/inward/record.url?scp=84882393605&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84882393605&partnerID=8YFLogxK

U2 - 10.1016/j.jalz.2013.03.005

DO - 10.1016/j.jalz.2013.03.005

M3 - Article

VL - 9

SP - 445

EP - 451

JO - Alzheimer's and Dementia

JF - Alzheimer's and Dementia

SN - 1552-5260

IS - 4

ER -