Military risk factors for Alzheimer's disease

Michael W. Weiner, Karl E. Friedl, Anthony Pacifico, Julie C. Chapman, Michael S. Jaffee, Deborah M. Little, Geoffrey T. Manley, Ann McKee, Ronald C. Petersen, Roger K. Pitman, Kristine Yaffe, Henrik Zetterberg, Robert Obana, Lisa J. Bain, Maria C. Carrillo

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

Traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD) are signature injuries of the wars in Iraq and Afghanistan and have been linked to an increased risk of Alzheimer's disease (AD) and other dementias. A meeting hosted by the Alzheimer's Association and the Veterans' Health Research Institute (NCIRE) in May 2012 brought together experts from the U.S. military and academic medical centers around the world to discuss current evidence and hypotheses regarding the pathophysiological mechanisms linking TBI, PTSD, and AD. Studies underway in civilian and military populations were highlighted, along with new research initiatives such as a study to extend the Alzheimer's Disease Neuroimaging Initiative (ADNI) to a population of veterans exposed to TBI and PTSD. Greater collaboration and data sharing among diverse research groups is needed to advance an understanding and appropriate interventions in this continuum of military injuries and neurodegenerative disease in the aging veteran.

Original languageEnglish (US)
Pages (from-to)445-451
Number of pages7
JournalAlzheimer's and Dementia
Volume9
Issue number4
DOIs
StatePublished - Jul 2013

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Keywords

  • Alzheimer's Disease Neuroimaging Initiative
  • Alzheimer's disease
  • Apolipoprotein E e4
  • Beta-amyloid
  • Biomarkers
  • Blast injury
  • Chronic traumatic encephalopathy
  • Military medicine
  • Posttraumatic stress disorder
  • Risk factors
  • Tau
  • Traumatic brain injury
  • Veterans
  • Vietnam

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

Cite this

Weiner, M. W., Friedl, K. E., Pacifico, A., Chapman, J. C., Jaffee, M. S., Little, D. M., Manley, G. T., McKee, A., Petersen, R. C., Pitman, R. K., Yaffe, K., Zetterberg, H., Obana, R., Bain, L. J., & Carrillo, M. C. (2013). Military risk factors for Alzheimer's disease. Alzheimer's and Dementia, 9(4), 445-451. https://doi.org/10.1016/j.jalz.2013.03.005