Military risk factors for Alzheimer's disease

Michael W. Weiner; Karl E. Friedl; Anthony Pacifico; Julie C. Chapman; Michael S. Jaffee; Deborah M. Little; Geoffrey T. Manley; Ann McKee; Ronald C. Petersen; Roger K. Pitman; Kristine Yaffe; Henrik Zetterberg; Robert Obana; Lisa J. Bain; Maria C. Carrillo

doi:10.1016/j.jalz.2013.03.005

Military risk factors for Alzheimer's disease

Michael W. Weiner, Karl E. Friedl, Anthony Pacifico, Julie C. Chapman, Michael S. Jaffee, Deborah M. Little, Geoffrey T. Manley, Ann McKee, Ronald C. Petersen, Roger K. Pitman, Kristine Yaffe, Henrik Zetterberg, Robert Obana, Lisa J. Bain, Maria C. Carrillo

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

Traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD) are signature injuries of the wars in Iraq and Afghanistan and have been linked to an increased risk of Alzheimer's disease (AD) and other dementias. A meeting hosted by the Alzheimer's Association and the Veterans' Health Research Institute (NCIRE) in May 2012 brought together experts from the U.S. military and academic medical centers around the world to discuss current evidence and hypotheses regarding the pathophysiological mechanisms linking TBI, PTSD, and AD. Studies underway in civilian and military populations were highlighted, along with new research initiatives such as a study to extend the Alzheimer's Disease Neuroimaging Initiative (ADNI) to a population of veterans exposed to TBI and PTSD. Greater collaboration and data sharing among diverse research groups is needed to advance an understanding and appropriate interventions in this continuum of military injuries and neurodegenerative disease in the aging veteran.

Original language	English (US)
Pages (from-to)	445-451
Number of pages	7
Journal	Alzheimer's and Dementia
Volume	9
Issue number	4
DOIs	https://doi.org/10.1016/j.jalz.2013.03.005
State	Published - Jul 2013

Keywords

Alzheimer's Disease Neuroimaging Initiative
Alzheimer's disease
Apolipoprotein E e4
Beta-amyloid
Biomarkers
Blast injury
Chronic traumatic encephalopathy
Military medicine
Posttraumatic stress disorder
Risk factors
Tau
Traumatic brain injury
Veterans
Vietnam

ASJC Scopus subject areas

Epidemiology
Health Policy
Developmental Neuroscience
Clinical Neurology
Geriatrics and Gerontology
Cellular and Molecular Neuroscience
Psychiatry and Mental health

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10.1016/j.jalz.2013.03.005

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@article{aff4153cf9cc4f1291d1ed67b01cb93e,

title = "Military risk factors for Alzheimer's disease",

abstract = "Traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD) are signature injuries of the wars in Iraq and Afghanistan and have been linked to an increased risk of Alzheimer's disease (AD) and other dementias. A meeting hosted by the Alzheimer's Association and the Veterans' Health Research Institute (NCIRE) in May 2012 brought together experts from the U.S. military and academic medical centers around the world to discuss current evidence and hypotheses regarding the pathophysiological mechanisms linking TBI, PTSD, and AD. Studies underway in civilian and military populations were highlighted, along with new research initiatives such as a study to extend the Alzheimer's Disease Neuroimaging Initiative (ADNI) to a population of veterans exposed to TBI and PTSD. Greater collaboration and data sharing among diverse research groups is needed to advance an understanding and appropriate interventions in this continuum of military injuries and neurodegenerative disease in the aging veteran.",

keywords = "Alzheimer's Disease Neuroimaging Initiative, Alzheimer's disease, Apolipoprotein E e4, Beta-amyloid, Biomarkers, Blast injury, Chronic traumatic encephalopathy, Military medicine, Posttraumatic stress disorder, Risk factors, Tau, Traumatic brain injury, Veterans, Vietnam",

author = "Weiner, {Michael W.} and Friedl, {Karl E.} and Anthony Pacifico and Chapman, {Julie C.} and Jaffee, {Michael S.} and Little, {Deborah M.} and Manley, {Geoffrey T.} and Ann McKee and Petersen, {Ronald C.} and Pitman, {Roger K.} and Kristine Yaffe and Henrik Zetterberg and Robert Obana and Bain, {Lisa J.} and Carrillo, {Maria C.}",

note = "Funding Information: The Alzheimer's Disease Neuroimaging Initiative (ADNI) is an ongoing, longitudinal, multicenter study supported by the National Institutes of Health (NIH) and private industry sponsors. Launched in 2003, ADNI is a public-private partnership among federal agencies (NIH, U.S. Food and Drug Administration), pharmaceutical companies, and nonprofit philanthropic organizations, including the Alzheimer's Association. The primary goal of ADNI is to develop, validate, and standardize the use of neuroimaging as an AD biomarker for use in clinical trials. Data generated by ADNI is made available on a public database (UCLA/LONI/ADNI). This database includes clinical data and the imaging data archive from where investigators may upload MRI and PET scans. The ADNI/LONI database is available to all qualified scientists and has supported the publication of more than 300 papers [45] . ",

year = "2013",

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doi = "10.1016/j.jalz.2013.03.005",

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T1 - Military risk factors for Alzheimer's disease

AU - Weiner, Michael W.

AU - Friedl, Karl E.

AU - Pacifico, Anthony

AU - Chapman, Julie C.

AU - Jaffee, Michael S.

AU - Little, Deborah M.

AU - Manley, Geoffrey T.

AU - McKee, Ann

AU - Petersen, Ronald C.

AU - Pitman, Roger K.

AU - Yaffe, Kristine

AU - Zetterberg, Henrik

AU - Obana, Robert

AU - Bain, Lisa J.

AU - Carrillo, Maria C.

N1 - Funding Information: The Alzheimer's Disease Neuroimaging Initiative (ADNI) is an ongoing, longitudinal, multicenter study supported by the National Institutes of Health (NIH) and private industry sponsors. Launched in 2003, ADNI is a public-private partnership among federal agencies (NIH, U.S. Food and Drug Administration), pharmaceutical companies, and nonprofit philanthropic organizations, including the Alzheimer's Association. The primary goal of ADNI is to develop, validate, and standardize the use of neuroimaging as an AD biomarker for use in clinical trials. Data generated by ADNI is made available on a public database (UCLA/LONI/ADNI). This database includes clinical data and the imaging data archive from where investigators may upload MRI and PET scans. The ADNI/LONI database is available to all qualified scientists and has supported the publication of more than 300 papers [45] .

PY - 2013/7

Y1 - 2013/7

N2 - Traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD) are signature injuries of the wars in Iraq and Afghanistan and have been linked to an increased risk of Alzheimer's disease (AD) and other dementias. A meeting hosted by the Alzheimer's Association and the Veterans' Health Research Institute (NCIRE) in May 2012 brought together experts from the U.S. military and academic medical centers around the world to discuss current evidence and hypotheses regarding the pathophysiological mechanisms linking TBI, PTSD, and AD. Studies underway in civilian and military populations were highlighted, along with new research initiatives such as a study to extend the Alzheimer's Disease Neuroimaging Initiative (ADNI) to a population of veterans exposed to TBI and PTSD. Greater collaboration and data sharing among diverse research groups is needed to advance an understanding and appropriate interventions in this continuum of military injuries and neurodegenerative disease in the aging veteran.

AB - Traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD) are signature injuries of the wars in Iraq and Afghanistan and have been linked to an increased risk of Alzheimer's disease (AD) and other dementias. A meeting hosted by the Alzheimer's Association and the Veterans' Health Research Institute (NCIRE) in May 2012 brought together experts from the U.S. military and academic medical centers around the world to discuss current evidence and hypotheses regarding the pathophysiological mechanisms linking TBI, PTSD, and AD. Studies underway in civilian and military populations were highlighted, along with new research initiatives such as a study to extend the Alzheimer's Disease Neuroimaging Initiative (ADNI) to a population of veterans exposed to TBI and PTSD. Greater collaboration and data sharing among diverse research groups is needed to advance an understanding and appropriate interventions in this continuum of military injuries and neurodegenerative disease in the aging veteran.

KW - Alzheimer's Disease Neuroimaging Initiative

KW - Alzheimer's disease

KW - Apolipoprotein E e4

KW - Beta-amyloid

KW - Biomarkers

KW - Blast injury

KW - Chronic traumatic encephalopathy

KW - Military medicine

KW - Posttraumatic stress disorder

KW - Risk factors

KW - Tau

KW - Traumatic brain injury

KW - Veterans

KW - Vietnam

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DO - 10.1016/j.jalz.2013.03.005

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AN - SCOPUS:84882393605

SN - 1552-5260

VL - 9

SP - 445

EP - 451

JO - Alzheimer's and Dementia

JF - Alzheimer's and Dementia

IS - 4

ER -

Military risk factors for Alzheimer's disease

Abstract

Keywords

ASJC Scopus subject areas

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