Mild cognitive impairment: Ten years later

Ronald C. Petersen, Rosebud O. Roberts, David S. Knopman, Bradley F. Boeve, Yonas E. Geda, Robert J. Ivnik, Glenn E. Smith, Clifford R. Jack

Research output: Contribution to journalReview article

791 Scopus citations

Abstract

In the past 10 years, there has been a virtual explosion in the literature concerning the construct of mild cognitive impairment. The interest in this topic demonstrates the increasing emphasis on the identification of the earliest features of cognitive disorders such as Alzheimer disease and other dementias. Mild cognitive impairment represents the earliest clinical features of these conditions and, hence, has become a focus of clinical, epidemiologic, neuroimaging, biomarker, neuropathological, disease mechanism, and clinical trials research. This review summarizes the progress that has been made while also recognizing the challenges that remain.

Original languageEnglish (US)
Pages (from-to)1447-1455
Number of pages9
JournalArchives of neurology
Volume66
Issue number12
DOIs
StatePublished - Dec 1 2009

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ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

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