Microvascular complications in cystic fibrosis-related diabetes

Sarah Jane Schwarzenberg, William Thomas, Timothy Olsen, Trish Grover, David Walk, Carlos Milla, Antoinette Moran

Research output: Contribution to journalReview article

115 Citations (Scopus)

Abstract

OBJECTIVE - The incidence of cystic fibrosis-related diabetes (CFRD) and the prevalence of diabetic microvascular complications were determined at the University of Minnesota. RESEARCH DESIGN AND METHODS - Cystic fibrosis patients have undergone annual oral glucose tolerance testing since 1990. Database review was performed to determine diabetes duration and the results of annual urine albumin-to-creatinine ratio (Ualb:Cr) screening and dilated retinal exams. In addition, 59 individuals underwent detailed retinopathy, nephropathy, neuropathy, and gastroenterpathy screening. RESULTS - During 1990-2005, 775 patients aged ≥6 years were followed. CFRD was diagnosed by an oral glucose tolerance test or fasting hyperglycemia in 285 subjects (52% female), 64% of whom had fasting hyperglycemia. Most patients with CFRD without fasting hyperglycemia progressed to CFRD with fasting hyperglycemia over time. No subject with CFRD without fasting hyperglycemia had retinopathy or abnormal Ualb:Cr. In CFRD subjects with fasting hyperglycemia and diabetes for ≥10 years, 14% had microalbuminuria and 16% had retinopathy. Autonomic neuropathy and gastrointestinal symptoms each were seen in 52% and somatic abnormalities in 22% of patients with or without fasting hyperglycemia. CONCLUSIONS - Diabetic microvascular complications occur in CFRD, although the prevalence of retinopathy and nephropathy appears to be less than that found in other forms of diabetes. Annual complication screening should occur after known diabetes duration of 5 years in patients with CFRD with fasting hyperglycemia.

Original languageEnglish (US)
Pages (from-to)1056-1061
Number of pages6
JournalDiabetes care
Volume30
Issue number5
DOIs
StatePublished - May 1 2007
Externally publishedYes

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Cystic Fibrosis
Hyperglycemia
Fasting
Diabetes Complications
Glucose Tolerance Test
Albumins
Creatinine
Research Design
Urine
Databases
Incidence

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Schwarzenberg, S. J., Thomas, W., Olsen, T., Grover, T., Walk, D., Milla, C., & Moran, A. (2007). Microvascular complications in cystic fibrosis-related diabetes. Diabetes care, 30(5), 1056-1061. https://doi.org/10.2337/dc06-1576

Microvascular complications in cystic fibrosis-related diabetes. / Schwarzenberg, Sarah Jane; Thomas, William; Olsen, Timothy; Grover, Trish; Walk, David; Milla, Carlos; Moran, Antoinette.

In: Diabetes care, Vol. 30, No. 5, 01.05.2007, p. 1056-1061.

Research output: Contribution to journalReview article

Schwarzenberg, SJ, Thomas, W, Olsen, T, Grover, T, Walk, D, Milla, C & Moran, A 2007, 'Microvascular complications in cystic fibrosis-related diabetes', Diabetes care, vol. 30, no. 5, pp. 1056-1061. https://doi.org/10.2337/dc06-1576
Schwarzenberg SJ, Thomas W, Olsen T, Grover T, Walk D, Milla C et al. Microvascular complications in cystic fibrosis-related diabetes. Diabetes care. 2007 May 1;30(5):1056-1061. https://doi.org/10.2337/dc06-1576
Schwarzenberg, Sarah Jane ; Thomas, William ; Olsen, Timothy ; Grover, Trish ; Walk, David ; Milla, Carlos ; Moran, Antoinette. / Microvascular complications in cystic fibrosis-related diabetes. In: Diabetes care. 2007 ; Vol. 30, No. 5. pp. 1056-1061.
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