Microthalamotomy effect during deep brain stimulation: Potential involvement of adenosine and glutamate efflux

Su-Youne Chang, Young Min Shon, Filippo Agnesi, Kendall H Lee

Research output: Chapter in Book/Report/Conference proceedingConference contribution

30 Citations (Scopus)

Abstract

Deep brain stimulation (DBS) of the thalamus is widely used in humans to treat essential tremor and tremor dominant Parkinson's disease. After DBS lead implantation, tremor is often reduced even without electrical stimulation. Often called "microthalamotomy" effect, the exact mechanism is unknown, although it is presumed to be due to micro lesioning. Here, we tested whether microthalamotomy effect may, in fact, be mediated via release of neurotransmitters adenosine and glutamate, using fast scan cyclic voltammetry (FSCV) and amperometry, respectively. Implantation of microelectrodes into the ventrolateral (VL) thalamus of the rat resulted in transient rise in adenosine and glutamate level from mechanical stimulation. Similarly, high frequency stimulation (100 - 130 Hz) of the VL thalamus also resulted in adenosine and glutamate release. These results suggest that glutamate and adenosine release may be an important and unappreciated mechanism whereby mechanical stimulation via electrode implantation procedure may achieve the microthalamotomy effect.

Original languageEnglish (US)
Title of host publicationProceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
Pages3294-3297
Number of pages4
DOIs
StatePublished - 2009
Event31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 - Minneapolis, MN, United States
Duration: Sep 2 2009Sep 6 2009

Other

Other31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
CountryUnited States
CityMinneapolis, MN
Period9/2/099/6/09

Fingerprint

Deep Brain Stimulation
Adenosine
Glutamic Acid
Brain
Ventral Thalamic Nuclei
Microelectrodes
Tremor
Cyclic voltammetry
Rats
Lead
Essential Tremor
Electrodes
Thalamus
Electric Stimulation
Neurotransmitter Agents
Parkinson Disease

ASJC Scopus subject areas

  • Cell Biology
  • Developmental Biology
  • Biomedical Engineering
  • Medicine(all)

Cite this

Chang, S-Y., Shon, Y. M., Agnesi, F., & Lee, K. H. (2009). Microthalamotomy effect during deep brain stimulation: Potential involvement of adenosine and glutamate efflux. In Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 (pp. 3294-3297). [5333735] https://doi.org/10.1109/IEMBS.2009.5333735

Microthalamotomy effect during deep brain stimulation : Potential involvement of adenosine and glutamate efflux. / Chang, Su-Youne; Shon, Young Min; Agnesi, Filippo; Lee, Kendall H.

Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009. 2009. p. 3294-3297 5333735.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Chang, S-Y, Shon, YM, Agnesi, F & Lee, KH 2009, Microthalamotomy effect during deep brain stimulation: Potential involvement of adenosine and glutamate efflux. in Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009., 5333735, pp. 3294-3297, 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009, Minneapolis, MN, United States, 9/2/09. https://doi.org/10.1109/IEMBS.2009.5333735
Chang S-Y, Shon YM, Agnesi F, Lee KH. Microthalamotomy effect during deep brain stimulation: Potential involvement of adenosine and glutamate efflux. In Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009. 2009. p. 3294-3297. 5333735 https://doi.org/10.1109/IEMBS.2009.5333735
Chang, Su-Youne ; Shon, Young Min ; Agnesi, Filippo ; Lee, Kendall H. / Microthalamotomy effect during deep brain stimulation : Potential involvement of adenosine and glutamate efflux. Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009. 2009. pp. 3294-3297
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