TY - JOUR
T1 - Microsurgery for Recurrent Vestibular Schwannoma after Previous Gross Total Resection
AU - Perry, Avital
AU - Graffeo, Christopher S.
AU - Copeland, William R.
AU - Carlson, Matthew L.
AU - Neff, Brian A.
AU - Driscoll, Colin L.
AU - Link, Michael J.
N1 - Publisher Copyright:
Copyright © 2017 Otology & Neurotology, Inc.
PY - 2017/7/1
Y1 - 2017/7/1
N2 - Objective: To present a single-institution experience and supportive systematic literature review examining outcomes after repeat microsurgery for recurrent vestibular schwannoma (VS) following previous gross total resection (GTR). Study Design: Retrospective review of prospectively maintained VS database. Systematic literature review. Setting: Tertiary referral center. Patients: Six proven VS recurrences after primary GTR, treated via repeat microsurgery. Intervention: Repeat microsurgery. Main Outcome Measures: Facial nerve function, extent-of-resection, time-to-repeat surgery, same versus alternate approach at repeat surgery (relative to primary operation). Results: GTR was achieved in four (67%). House-Brackmann (HB) grade I-II facial nerve function was achieved in five (87%), including one that improved from preoperative HB grade V. An alternate surgical approach was chosen in four (67%). Systematic review identified four studies documenting 50 cases with patient-specific outcomes after repeat microsurgery for recurrent VS. Our cohort had significantly longer mean time-to-repeat surgery (117 vs. 64 months, p = 0.03), was significantly less likely to have HB III-VI function postrepeat (17% vs. 68%, p = 0.04), and was significantly less likely to undergo same approach surgery (33% vs. 90%, p = 0.0002); rates of GTR were nonsignificant (67% vs. 94%, p = 0.1). Conclusion: We report a six-patient series of microsurgery for recurrent VS after GTR, and the first systematic review of this rare and challenging entity. Anecdotally, our findings suggest that an alternate surgical approach may facilitate easier access to the tumor, with less scar encountered during the approach. Our results confirm that repeat microsurgery for recurrent VS is safe and effective, even for larger tumors not typically amenable to stereotactic radiosurgery.
AB - Objective: To present a single-institution experience and supportive systematic literature review examining outcomes after repeat microsurgery for recurrent vestibular schwannoma (VS) following previous gross total resection (GTR). Study Design: Retrospective review of prospectively maintained VS database. Systematic literature review. Setting: Tertiary referral center. Patients: Six proven VS recurrences after primary GTR, treated via repeat microsurgery. Intervention: Repeat microsurgery. Main Outcome Measures: Facial nerve function, extent-of-resection, time-to-repeat surgery, same versus alternate approach at repeat surgery (relative to primary operation). Results: GTR was achieved in four (67%). House-Brackmann (HB) grade I-II facial nerve function was achieved in five (87%), including one that improved from preoperative HB grade V. An alternate surgical approach was chosen in four (67%). Systematic review identified four studies documenting 50 cases with patient-specific outcomes after repeat microsurgery for recurrent VS. Our cohort had significantly longer mean time-to-repeat surgery (117 vs. 64 months, p = 0.03), was significantly less likely to have HB III-VI function postrepeat (17% vs. 68%, p = 0.04), and was significantly less likely to undergo same approach surgery (33% vs. 90%, p = 0.0002); rates of GTR were nonsignificant (67% vs. 94%, p = 0.1). Conclusion: We report a six-patient series of microsurgery for recurrent VS after GTR, and the first systematic review of this rare and challenging entity. Anecdotally, our findings suggest that an alternate surgical approach may facilitate easier access to the tumor, with less scar encountered during the approach. Our results confirm that repeat microsurgery for recurrent VS is safe and effective, even for larger tumors not typically amenable to stereotactic radiosurgery.
KW - Microsurgery
KW - Recurrence
KW - Repeat surgery
KW - Vestibular schwannoma
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UR - http://www.scopus.com/inward/citedby.url?scp=85020427441&partnerID=8YFLogxK
U2 - 10.1097/MAO.0000000000001402
DO - 10.1097/MAO.0000000000001402
M3 - Article
C2 - 28595258
AN - SCOPUS:85020427441
SN - 1531-7129
VL - 38
SP - 882
EP - 888
JO - Otology and Neurotology
JF - Otology and Neurotology
IS - 6
ER -