MicroRNA control of bone formation and homeostasis

Jane B. Lian, Gary S. Stein, Andre J van Wijnen, Janet L. Stein, Mohammad Q. Hassan, Tripti Gaur, Ying Zhang

Research output: Contribution to journalArticle

324 Citations (Scopus)

Abstract

MicroRNAs (miRNAs) repress cellular protein levels to provide a sophisticated parameter of gene regulation that coordinates a broad spectrum of biological processes. Bone organogenesis is a complex process involving the differentiation and crosstalk of multiple cell types for formation and remodeling of the skeleton. Inhibition of mRNA translation by miRNAs has emerged as an important regulator of developmental osteogenic signaling pathways, osteoblast growth and differentiation, osteoclast-mediated bone resorption activity and bone homeostasis in the adult skeleton. miRNAs control multiple layers of gene regulation for bone development and postnatal functions, from the initial response of stem/progenitor cells to the structural and metabolic activity of the mature tissue. This Review brings into focus an emerging concept of bone-regulating miRNAs, the evidence for which has been gathered largely from in vivo mouse models and in vitro studies in human and mouse skeletal cell populations. Characterization of miRNAs that operate through tissue-specific transcription factors in osteoblast and osteoclast lineage cells, as well as intricate feedforward and reverse loops, has provided novel insights into the supervision of signaling pathways and regulatory networks controlling normal bone formation and turnover. The current knowledge of miRNAs characteristic of human pathologic disorders of the skeleton is presented with a future goal towards translational studies.

Original languageEnglish (US)
Pages (from-to)212-227
Number of pages16
JournalNature Reviews Endocrinology
Volume8
Issue number4
DOIs
StatePublished - Apr 2012
Externally publishedYes

Fingerprint

MicroRNAs
Osteogenesis
Homeostasis
Skeleton
Osteoclasts
Osteoblasts
Bone and Bones
Stem Cells
Biological Phenomena
Organogenesis
Bone Remodeling
Bone Development
Protein Biosynthesis
Bone Resorption
Genes
Transcription Factors
Growth
Population
Proteins

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Lian, J. B., Stein, G. S., van Wijnen, A. J., Stein, J. L., Hassan, M. Q., Gaur, T., & Zhang, Y. (2012). MicroRNA control of bone formation and homeostasis. Nature Reviews Endocrinology, 8(4), 212-227. https://doi.org/10.1038/nrendo.2011.234

MicroRNA control of bone formation and homeostasis. / Lian, Jane B.; Stein, Gary S.; van Wijnen, Andre J; Stein, Janet L.; Hassan, Mohammad Q.; Gaur, Tripti; Zhang, Ying.

In: Nature Reviews Endocrinology, Vol. 8, No. 4, 04.2012, p. 212-227.

Research output: Contribution to journalArticle

Lian, JB, Stein, GS, van Wijnen, AJ, Stein, JL, Hassan, MQ, Gaur, T & Zhang, Y 2012, 'MicroRNA control of bone formation and homeostasis', Nature Reviews Endocrinology, vol. 8, no. 4, pp. 212-227. https://doi.org/10.1038/nrendo.2011.234
Lian JB, Stein GS, van Wijnen AJ, Stein JL, Hassan MQ, Gaur T et al. MicroRNA control of bone formation and homeostasis. Nature Reviews Endocrinology. 2012 Apr;8(4):212-227. https://doi.org/10.1038/nrendo.2011.234
Lian, Jane B. ; Stein, Gary S. ; van Wijnen, Andre J ; Stein, Janet L. ; Hassan, Mohammad Q. ; Gaur, Tripti ; Zhang, Ying. / MicroRNA control of bone formation and homeostasis. In: Nature Reviews Endocrinology. 2012 ; Vol. 8, No. 4. pp. 212-227.
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