MicroRNA-34c inversely couples the biological functions of the runt-related transcription factor RUNX2 and the tumor suppressor p53 in osteosarcoma

Margaretha Van Der Deen, Hanna Taipaleenmäki, Ying Zhang, Nadiya M. Teplyuk, Anurag Gupta, Senthilkumar Cinghu, Kristen Shogren, Avudaiappan Maran, Michael J. Yaszemski, Ling Ling, Simon M. Cool, David T. Leong, Christian Dierkes, Jozef Zustin, Manuel Salto-Tellez, Yoshiaki Ito, Suk Chul Bae, Maria Zielenska, Jeremy A. Squire, Jane B. LianJanet L. Stein, Gerard P. Zambetti, Stephen N. Jones, Mario Galindo, Eric Hesse, Gary S. Stein, Andre J. Van Wijnen

Research output: Contribution to journalArticle

71 Scopus citations

Abstract

Background: Osteosarcoma (OS) is associated with loss of tumor suppressor p53 and increased Runx2. Results: Runx2 and p53 levels are inversely correlated in OS. miR-34c, which targets Runx2, is absent in OS and elevated by p53. Conclusion: p53, miR-34c, and Runx2 form a regulatory loop that is compromised in OS. Significance: RUNX2 could be targeted by miR-34c to prevent OS growth.

Original languageEnglish (US)
Pages (from-to)21307-21319
Number of pages13
JournalJournal of Biological Chemistry
Volume288
Issue number29
DOIs
StatePublished - Jul 19 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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    Van Der Deen, M., Taipaleenmäki, H., Zhang, Y., Teplyuk, N. M., Gupta, A., Cinghu, S., Shogren, K., Maran, A., Yaszemski, M. J., Ling, L., Cool, S. M., Leong, D. T., Dierkes, C., Zustin, J., Salto-Tellez, M., Ito, Y., Bae, S. C., Zielenska, M., Squire, J. A., ... Van Wijnen, A. J. (2013). MicroRNA-34c inversely couples the biological functions of the runt-related transcription factor RUNX2 and the tumor suppressor p53 in osteosarcoma. Journal of Biological Chemistry, 288(29), 21307-21319. https://doi.org/10.1074/jbc.M112.445890