MicroRNA-34c inversely couples the biological functions of the runt-related transcription factor RUNX2 and the tumor suppressor p53 in osteosarcoma

Margaretha Van Der Deen; Hanna Taipaleenmäki; Ying Zhang; Nadiya M. Teplyuk; Anurag Gupta; Senthilkumar Cinghu; Kristen Shogren; Avudaiappan Maran; Michael J. Yaszemski; Ling Ling; Simon M. Cool; David T. Leong; Christian Dierkes; Jozef Zustin; Manuel Salto-Tellez; Yoshiaki Ito; Suk Chul Bae; Maria Zielenska; Jeremy A. Squire; Jane B. Lian; Janet L. Stein; Gerard P. Zambetti; Stephen N. Jones; Mario Galindo; Eric Hesse; Gary S. Stein; Andre J. Van Wijnen

doi:10.1074/jbc.M112.445890

MicroRNA-34c inversely couples the biological functions of the runt-related transcription factor RUNX2 and the tumor suppressor p53 in osteosarcoma

Margaretha Van Der Deen, Hanna Taipaleenmäki, Ying Zhang, Nadiya M. Teplyuk, Anurag Gupta, Senthilkumar Cinghu, Kristen Shogren, Avudaiappan Maran, Michael J. Yaszemski, Ling Ling, Simon M. Cool, David T. Leong, Christian Dierkes, Jozef Zustin, Manuel Salto-Tellez, Yoshiaki Ito, Suk Chul Bae, Maria Zielenska, Jeremy A. Squire, Jane B. LianJanet L. Stein, Gerard P. Zambetti, Stephen N. Jones, Mario Galindo, Eric Hesse, Gary S. Stein, Andre J. Van Wijnen

Orthopedic Surgery

Research output: Contribution to journal › Article › peer-review

77 Scopus citations

Abstract

Background: Osteosarcoma (OS) is associated with loss of tumor suppressor p53 and increased Runx2. Results: Runx2 and p53 levels are inversely correlated in OS. miR-34c, which targets Runx2, is absent in OS and elevated by p53. Conclusion: p53, miR-34c, and Runx2 form a regulatory loop that is compromised in OS. Significance: RUNX2 could be targeted by miR-34c to prevent OS growth.

Original language	English (US)
Pages (from-to)	21307-21319
Number of pages	13
Journal	Journal of Biological Chemistry
Volume	288
Issue number	29
DOIs	https://doi.org/10.1074/jbc.M112.445890
State	Published - Jul 19 2013

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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Van Der Deen, M., Taipaleenmäki, H., Zhang, Y., Teplyuk, N. M., Gupta, A., Cinghu, S., Shogren, K., Maran, A., Yaszemski, M. J., Ling, L., Cool, S. M., Leong, D. T., Dierkes, C., Zustin, J., Salto-Tellez, M., Ito, Y., Bae, S. C., Zielenska, M., Squire, J. A., ... Van Wijnen, A. J. (2013). MicroRNA-34c inversely couples the biological functions of the runt-related transcription factor RUNX2 and the tumor suppressor p53 in osteosarcoma. Journal of Biological Chemistry, 288(29), 21307-21319. https://doi.org/10.1074/jbc.M112.445890

Van Der Deen, M, Taipaleenmäki, H, Zhang, Y, Teplyuk, NM, Gupta, A, Cinghu, S, Shogren, K, Maran, A, Yaszemski, MJ, Ling, L, Cool, SM, Leong, DT, Dierkes, C, Zustin, J, Salto-Tellez, M, Ito, Y, Bae, SC, Zielenska, M, Squire, JA, Lian, JB, Stein, JL, Zambetti, GP, Jones, SN, Galindo, M, Hesse, E, Stein, GS & Van Wijnen, AJ 2013, 'MicroRNA-34c inversely couples the biological functions of the runt-related transcription factor RUNX2 and the tumor suppressor p53 in osteosarcoma', Journal of Biological Chemistry, vol. 288, no. 29, pp. 21307-21319. https://doi.org/10.1074/jbc.M112.445890

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title = "MicroRNA-34c inversely couples the biological functions of the runt-related transcription factor RUNX2 and the tumor suppressor p53 in osteosarcoma",

abstract = "Background: Osteosarcoma (OS) is associated with loss of tumor suppressor p53 and increased Runx2. Results: Runx2 and p53 levels are inversely correlated in OS. miR-34c, which targets Runx2, is absent in OS and elevated by p53. Conclusion: p53, miR-34c, and Runx2 form a regulatory loop that is compromised in OS. Significance: RUNX2 could be targeted by miR-34c to prevent OS growth.",

author = "{Van Der Deen}, Margaretha and Hanna Taipaleenm{\"a}ki and Ying Zhang and Teplyuk, {Nadiya M.} and Anurag Gupta and Senthilkumar Cinghu and Kristen Shogren and Avudaiappan Maran and Yaszemski, {Michael J.} and Ling Ling and Cool, {Simon M.} and Leong, {David T.} and Christian Dierkes and Jozef Zustin and Manuel Salto-Tellez and Yoshiaki Ito and Bae, {Suk Chul} and Maria Zielenska and Squire, {Jeremy A.} and Lian, {Jane B.} and Stein, {Janet L.} and Zambetti, {Gerard P.} and Jones, {Stephen N.} and Mario Galindo and Eric Hesse and Stein, {Gary S.} and {Van Wijnen}, {Andre J.}",

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doi = "10.1074/jbc.M112.445890",

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T1 - MicroRNA-34c inversely couples the biological functions of the runt-related transcription factor RUNX2 and the tumor suppressor p53 in osteosarcoma

AU - Van Der Deen, Margaretha

AU - Taipaleenmäki, Hanna

AU - Zhang, Ying

AU - Teplyuk, Nadiya M.

AU - Gupta, Anurag

AU - Cinghu, Senthilkumar

AU - Shogren, Kristen

AU - Maran, Avudaiappan

AU - Yaszemski, Michael J.

AU - Ling, Ling

AU - Cool, Simon M.

AU - Leong, David T.

AU - Dierkes, Christian

AU - Zustin, Jozef

AU - Salto-Tellez, Manuel

AU - Ito, Yoshiaki

AU - Bae, Suk Chul

AU - Zielenska, Maria

AU - Squire, Jeremy A.

AU - Lian, Jane B.

AU - Stein, Janet L.

AU - Zambetti, Gerard P.

AU - Jones, Stephen N.

AU - Galindo, Mario

AU - Hesse, Eric

AU - Stein, Gary S.

AU - Van Wijnen, Andre J.

PY - 2013/7/19

Y1 - 2013/7/19

N2 - Background: Osteosarcoma (OS) is associated with loss of tumor suppressor p53 and increased Runx2. Results: Runx2 and p53 levels are inversely correlated in OS. miR-34c, which targets Runx2, is absent in OS and elevated by p53. Conclusion: p53, miR-34c, and Runx2 form a regulatory loop that is compromised in OS. Significance: RUNX2 could be targeted by miR-34c to prevent OS growth.

AB - Background: Osteosarcoma (OS) is associated with loss of tumor suppressor p53 and increased Runx2. Results: Runx2 and p53 levels are inversely correlated in OS. miR-34c, which targets Runx2, is absent in OS and elevated by p53. Conclusion: p53, miR-34c, and Runx2 form a regulatory loop that is compromised in OS. Significance: RUNX2 could be targeted by miR-34c to prevent OS growth.

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MicroRNA-34c inversely couples the biological functions of the runt-related transcription factor RUNX2 and the tumor suppressor p53 in osteosarcoma

Abstract

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