TY - JOUR
T1 - Microporous polysaccharide hemospheres for management of laparoscopic trocar injury to the spleen
AU - Humphreys, Mitchell R.
AU - Castle, Erik P.
AU - Andrews, Paul E.
AU - Gettman, Matthew T.
AU - Ereth, Mark H.
PY - 2008/1
Y1 - 2008/1
N2 - Background: Management of iatrogenic injuries during laparoscopy can be arduous. Recent advancements in surgical hemostatic agents have provided beneficial therapeutic alternatives. This project evaluates microporous polysaccharide hemospheres (MPH), with demonstrated efficiency achieving topical hemostasis, in the setting of intracorporeal laparoscopic splenic injury. Methods: Four domestic female pigs were subjected to reproducible laparoscopic 12-mm and 5-mm trocar splenic injuries. Each surgery was an identical transperitoneal hand-assisted laparoscopic procedure. Hemostasis, or no bleeding after treatment, was achieved by measured dose applications of MPH. Results: The MPH successfully achieved hemostasis for all splenic injuries except in 1 case, where a 12-mm lesion transected the splenic artery. The mean time to hemostasis, applications of MPH, and estimated blood loss for the 5- and 12-mm injuries were 165.3 ± 45.7 and 200.7 ± 106.5 seconds, 1.3 ± .5 applications for both, and 12.0 ± 4.6 and 17.7 ± 9.1g, respectively. Conclusions: MPH represents a powerful hemostatic agent that demonstrated complete hemostasis for iatrogenic splenic injury.
AB - Background: Management of iatrogenic injuries during laparoscopy can be arduous. Recent advancements in surgical hemostatic agents have provided beneficial therapeutic alternatives. This project evaluates microporous polysaccharide hemospheres (MPH), with demonstrated efficiency achieving topical hemostasis, in the setting of intracorporeal laparoscopic splenic injury. Methods: Four domestic female pigs were subjected to reproducible laparoscopic 12-mm and 5-mm trocar splenic injuries. Each surgery was an identical transperitoneal hand-assisted laparoscopic procedure. Hemostasis, or no bleeding after treatment, was achieved by measured dose applications of MPH. Results: The MPH successfully achieved hemostasis for all splenic injuries except in 1 case, where a 12-mm lesion transected the splenic artery. The mean time to hemostasis, applications of MPH, and estimated blood loss for the 5- and 12-mm injuries were 165.3 ± 45.7 and 200.7 ± 106.5 seconds, 1.3 ± .5 applications for both, and 12.0 ± 4.6 and 17.7 ± 9.1g, respectively. Conclusions: MPH represents a powerful hemostatic agent that demonstrated complete hemostasis for iatrogenic splenic injury.
KW - Hemostatic agents
KW - Laparoscopic hemostasis
KW - Splenic injury
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U2 - 10.1016/j.amjsurg.2007.03.006
DO - 10.1016/j.amjsurg.2007.03.006
M3 - Article
C2 - 18070734
AN - SCOPUS:36849064898
SN - 0002-9610
VL - 195
SP - 99
EP - 103
JO - American journal of surgery
JF - American journal of surgery
IS - 1
ER -