Microglia and monocytes synergistically promote the transition from acute to chronic pain after nerve injury

Jiyun Peng, Nan Gu, Lijun Zhou, Ukpong B Eyo, Madhuvika Murugan, Wen Biao Gan, LongJun Wu

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

Microglia and peripheral monocytes contribute to hypersensitivity in rodent models of neuropathic pain. However, the precise respective function of microglia and peripheral monocytes has not been investigated in these models. To address this question, here we combined transgenic mice and pharmacological tools to specifically and temporally control the depletion of microglia and monocytes in a mouse model of spinal nerve transection (SNT). We found that although microglia and monocytes are required during the initiation of mechanical allodynia or thermal hyperalgesia, these cells may not be as important for the maintenance of hypersensitivity. Moreover, we demonstrated that either resident microglia or peripheral monocytes are sufficient in gating neuropathic pain after SNT. We propose that resident microglia and peripheral monocytes act synergistically to initiate hypersensitivity and promote the transition from acute to chronic pain after peripheral nerve injury.

Original languageEnglish (US)
Article number12029
JournalNature Communications
Volume7
DOIs
StatePublished - Jun 28 2016
Externally publishedYes

Fingerprint

monocytes
pain
nerves
Microglia
Chronic Pain
Monocytes
Hyperalgesia
Wounds and Injuries
Spinal Nerves
Hypersensitivity
Neuralgia
mice
Peripheral Nerve Injuries
rodents
Transgenic Mice
maintenance
Rodentia
depletion
Maintenance
Pharmacology

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Microglia and monocytes synergistically promote the transition from acute to chronic pain after nerve injury. / Peng, Jiyun; Gu, Nan; Zhou, Lijun; B Eyo, Ukpong; Murugan, Madhuvika; Gan, Wen Biao; Wu, LongJun.

In: Nature Communications, Vol. 7, 12029, 28.06.2016.

Research output: Contribution to journalArticle

Peng, Jiyun ; Gu, Nan ; Zhou, Lijun ; B Eyo, Ukpong ; Murugan, Madhuvika ; Gan, Wen Biao ; Wu, LongJun. / Microglia and monocytes synergistically promote the transition from acute to chronic pain after nerve injury. In: Nature Communications. 2016 ; Vol. 7.
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