Microbleeds in the logopenic variant of primary progressive aphasia

Jennifer L. Whitwell; Clifford R. Jack; Joseph R. Duffy; Edythe A. Strand; Jeffrey L. Gunter; Matthew L. Senjem; Matthew C. Murphy; Kejal Kantarci; Mary M. MacHulda; Val J. Lowe; Keith A. Josephs

doi:10.1016/j.jalz.2013.01.006

Microbleeds in the logopenic variant of primary progressive aphasia

Jennifer L. Whitwell, Clifford R. Jack, Joseph R. Duffy, Edythe A. Strand, Jeffrey L. Gunter, Matthew L. Senjem, Matthew C. Murphy, Kejal Kantarci, Mary M. MacHulda, Val J. Lowe, Keith A. Josephs

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Background: Microbleeds have been associated with Alzheimer's disease (AD), although it is unclear whether they occur in atypical presentations of AD, such as the logopenic variant of primary progressive aphasia (lvPPA). We aimed to assess the presence and clinical correlates of microbleeds in lvPPA. Methods: Thirteen lvPPA subjects underwent 3T T2*-weighted and fluid-attenuated inversion recovery magnetic resonance imaging and Pittsburgh compound B (PiB) positron emission tomography imaging. Microbleeds were identified on manual review and assigned a regional location. Total and regional white matter hyperintensity (WMH) burden was measured. Results: Microbleeds were observed in four lvPPA subjects (31%), most commonly in the frontal lobe. Subjects with microbleeds were older, more likely female, and had a greater burden of WMH than those without microbleeds. The regional distribution of microbleeds did not match the regional distribution of WMH. All cases were PiB positive. Conclusions: Microbleeds occur in approximately one third of subjects with lvPPA, with older women at the highest risk.

Original language	English (US)
Pages (from-to)	62-66
Number of pages	5
Journal	Alzheimer's and Dementia
Volume	10
Issue number	1
DOIs	https://doi.org/10.1016/j.jalz.2013.01.006
State	Published - Jan 2014

Keywords

Alzheimer's disease
Logopenic variant of primary progressive aphasia
Microbleeds
White matter hyperintensities

ASJC Scopus subject areas

Clinical Neurology
Geriatrics and Gerontology
Psychiatry and Mental health
Cellular and Molecular Neuroscience
Health Policy
Developmental Neuroscience
Epidemiology

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10.1016/j.jalz.2013.01.006

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@article{ba2467384b484746bf254b987e8ec7a2,

title = "Microbleeds in the logopenic variant of primary progressive aphasia",

abstract = "Background: Microbleeds have been associated with Alzheimer's disease (AD), although it is unclear whether they occur in atypical presentations of AD, such as the logopenic variant of primary progressive aphasia (lvPPA). We aimed to assess the presence and clinical correlates of microbleeds in lvPPA. Methods: Thirteen lvPPA subjects underwent 3T T2*-weighted and fluid-attenuated inversion recovery magnetic resonance imaging and Pittsburgh compound B (PiB) positron emission tomography imaging. Microbleeds were identified on manual review and assigned a regional location. Total and regional white matter hyperintensity (WMH) burden was measured. Results: Microbleeds were observed in four lvPPA subjects (31%), most commonly in the frontal lobe. Subjects with microbleeds were older, more likely female, and had a greater burden of WMH than those without microbleeds. The regional distribution of microbleeds did not match the regional distribution of WMH. All cases were PiB positive. Conclusions: Microbleeds occur in approximately one third of subjects with lvPPA, with older women at the highest risk.",

keywords = "Alzheimer's disease, Logopenic variant of primary progressive aphasia, Microbleeds, White matter hyperintensities",

author = "Whitwell, {Jennifer L.} and Jack, {Clifford R.} and Duffy, {Joseph R.} and Strand, {Edythe A.} and Gunter, {Jeffrey L.} and Senjem, {Matthew L.} and Murphy, {Matthew C.} and Kejal Kantarci and MacHulda, {Mary M.} and Lowe, {Val J.} and Josephs, {Keith A.}",

note = "Funding Information: The study was funded by the National Institute of on Deafness and Communication Disorders ( R01-DC010367 , PI Josephs). The authors acknowledge Samantha Wille for her contribution to image analysis. The authors have no conflicts of interest to disclose.",

year = "2014",

month = jan,

doi = "10.1016/j.jalz.2013.01.006",

language = "English (US)",

volume = "10",

pages = "62--66",

journal = "Alzheimer's and Dementia",

issn = "1552-5260",

publisher = "Elsevier Inc.",

number = "1",

}

TY - JOUR

T1 - Microbleeds in the logopenic variant of primary progressive aphasia

AU - Whitwell, Jennifer L.

AU - Jack, Clifford R.

AU - Duffy, Joseph R.

AU - Strand, Edythe A.

AU - Gunter, Jeffrey L.

AU - Senjem, Matthew L.

AU - Murphy, Matthew C.

AU - Kantarci, Kejal

AU - MacHulda, Mary M.

AU - Lowe, Val J.

AU - Josephs, Keith A.

N1 - Funding Information: The study was funded by the National Institute of on Deafness and Communication Disorders ( R01-DC010367 , PI Josephs). The authors acknowledge Samantha Wille for her contribution to image analysis. The authors have no conflicts of interest to disclose.

PY - 2014/1

Y1 - 2014/1

N2 - Background: Microbleeds have been associated with Alzheimer's disease (AD), although it is unclear whether they occur in atypical presentations of AD, such as the logopenic variant of primary progressive aphasia (lvPPA). We aimed to assess the presence and clinical correlates of microbleeds in lvPPA. Methods: Thirteen lvPPA subjects underwent 3T T2*-weighted and fluid-attenuated inversion recovery magnetic resonance imaging and Pittsburgh compound B (PiB) positron emission tomography imaging. Microbleeds were identified on manual review and assigned a regional location. Total and regional white matter hyperintensity (WMH) burden was measured. Results: Microbleeds were observed in four lvPPA subjects (31%), most commonly in the frontal lobe. Subjects with microbleeds were older, more likely female, and had a greater burden of WMH than those without microbleeds. The regional distribution of microbleeds did not match the regional distribution of WMH. All cases were PiB positive. Conclusions: Microbleeds occur in approximately one third of subjects with lvPPA, with older women at the highest risk.

AB - Background: Microbleeds have been associated with Alzheimer's disease (AD), although it is unclear whether they occur in atypical presentations of AD, such as the logopenic variant of primary progressive aphasia (lvPPA). We aimed to assess the presence and clinical correlates of microbleeds in lvPPA. Methods: Thirteen lvPPA subjects underwent 3T T2*-weighted and fluid-attenuated inversion recovery magnetic resonance imaging and Pittsburgh compound B (PiB) positron emission tomography imaging. Microbleeds were identified on manual review and assigned a regional location. Total and regional white matter hyperintensity (WMH) burden was measured. Results: Microbleeds were observed in four lvPPA subjects (31%), most commonly in the frontal lobe. Subjects with microbleeds were older, more likely female, and had a greater burden of WMH than those without microbleeds. The regional distribution of microbleeds did not match the regional distribution of WMH. All cases were PiB positive. Conclusions: Microbleeds occur in approximately one third of subjects with lvPPA, with older women at the highest risk.

KW - Alzheimer's disease

KW - Logopenic variant of primary progressive aphasia

KW - Microbleeds

KW - White matter hyperintensities

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EP - 66

JO - Alzheimer's and Dementia

JF - Alzheimer's and Dementia

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Microbleeds in the logopenic variant of primary progressive aphasia

Abstract

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