MHC epitopes of Ks and Dd restrict the same population of cytolytic T lymphocytes

John D. Tyler, Chella S. David

Research output: Contribution to journalArticlepeer-review


When A. SW (H-2s) mice are immunized with B10.S (H-2S) epidermal cells, cytolytic T lymphocytes are evoked that efficiently lyse B10.D2 (H-2d) as well as B10.S target cells. Immunogenetic analysis of this apparent H-2-unrestricted killing revealed that the most plausible explanation was a sharing of an H-2-restricting epitope by H-2KS and H-2Dd molecules.

Original languageEnglish (US)
Pages (from-to)457-464
Number of pages8
Issue number5
StatePublished - Sep 1983

ASJC Scopus subject areas

  • Immunology
  • Genetics


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