MHC epitopes of Ks and Dd restrict the same population of cytolytic T lymphocytes

John D. Tyler; Chella S. David

doi:10.1007/BF00696869

MHC epitopes of K^s and D^d restrict the same population of cytolytic T lymphocytes

John D. Tyler, Chella S. David

Immunology

Research output: Contribution to journal › Article › peer-review

Abstract

When A. SW (H-2^s) mice are immunized with B10.S (H-2^S) epidermal cells, cytolytic T lymphocytes are evoked that efficiently lyse B10.D2 (H-2^d) as well as B10.S target cells. Immunogenetic analysis of this apparent H-2-unrestricted killing revealed that the most plausible explanation was a sharing of an H-2-restricting epitope by H-2K^S and H-2D^d molecules.

Original language	English (US)
Pages (from-to)	457-464
Number of pages	8
Journal	Immunogenetics
Volume	17
Issue number	5
DOIs	https://doi.org/10.1007/BF00696869
State	Published - Sep 1983

ASJC Scopus subject areas

Immunology
Genetics

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10.1007/BF00696869

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title = "MHC epitopes of Ks and Dd restrict the same population of cytolytic T lymphocytes",

abstract = "When A. SW (H-2s) mice are immunized with B10.S (H-2S) epidermal cells, cytolytic T lymphocytes are evoked that efficiently lyse B10.D2 (H-2d) as well as B10.S target cells. Immunogenetic analysis of this apparent H-2-unrestricted killing revealed that the most plausible explanation was a sharing of an H-2-restricting epitope by H-2KS and H-2Dd molecules.",

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year = "1983",

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AU - Tyler, John D.

AU - David, Chella S.

PY - 1983/9

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N2 - When A. SW (H-2s) mice are immunized with B10.S (H-2S) epidermal cells, cytolytic T lymphocytes are evoked that efficiently lyse B10.D2 (H-2d) as well as B10.S target cells. Immunogenetic analysis of this apparent H-2-unrestricted killing revealed that the most plausible explanation was a sharing of an H-2-restricting epitope by H-2KS and H-2Dd molecules.

AB - When A. SW (H-2s) mice are immunized with B10.S (H-2S) epidermal cells, cytolytic T lymphocytes are evoked that efficiently lyse B10.D2 (H-2d) as well as B10.S target cells. Immunogenetic analysis of this apparent H-2-unrestricted killing revealed that the most plausible explanation was a sharing of an H-2-restricting epitope by H-2KS and H-2Dd molecules.

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ER -

MHC epitopes of K^s and D^d restrict the same population of cytolytic T lymphocytes

Abstract

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