Methotrexate induced seizures associated with acute reversible magnetic resonance imaging (MRI) changes in a patient with acute lymphoblastic leukemia

Ravi D. Rao; Jerry W. Swanson; Ramona S. DeJesus; Christopher H. Hunt; Ayalew Tefferi

doi:10.1080/10428190290026402

Methotrexate induced seizures associated with acute reversible magnetic resonance imaging (MRI) changes in a patient with acute lymphoblastic leukemia

Ravi D. Rao, Jerry W. Swanson, Ramona S. DeJesus, Christopher H. Hunt, Ayalew Tefferi

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

A 27-year-old woman with acute lymphoblastic leukemia (ALL) had an episode of generalized tonicclonic seizure after therapy with intrathecal and intravenous methotrexate (MTX). Magnetic resonance imaging (MRI) of her head showed meningeal, cortical and subcortical enhancement that was new when compared to a study done prior to therapy. Subsequent imaging 10 days later showed partial resolution of these findings. The association of seizures and MTX in ALL and the corresponding MRI changes are discussed.

Original language	English (US)
Pages (from-to)	1333-1336
Number of pages	4
Journal	Leukemia and Lymphoma
Volume	43
Issue number	6
DOIs	https://doi.org/10.1080/10428190290026402
State	Published - 2002

Keywords

Acute lymphocytic leukemia
MRI
Methotrexate
Neurotoxicity
Seizure

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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10.1080/10428190290026402

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title = "Methotrexate induced seizures associated with acute reversible magnetic resonance imaging (MRI) changes in a patient with acute lymphoblastic leukemia",

abstract = "A 27-year-old woman with acute lymphoblastic leukemia (ALL) had an episode of generalized tonicclonic seizure after therapy with intrathecal and intravenous methotrexate (MTX). Magnetic resonance imaging (MRI) of her head showed meningeal, cortical and subcortical enhancement that was new when compared to a study done prior to therapy. Subsequent imaging 10 days later showed partial resolution of these findings. The association of seizures and MTX in ALL and the corresponding MRI changes are discussed.",

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AU - Rao, Ravi D.

AU - Swanson, Jerry W.

AU - DeJesus, Ramona S.

AU - Hunt, Christopher H.

AU - Tefferi, Ayalew

PY - 2002

Y1 - 2002

N2 - A 27-year-old woman with acute lymphoblastic leukemia (ALL) had an episode of generalized tonicclonic seizure after therapy with intrathecal and intravenous methotrexate (MTX). Magnetic resonance imaging (MRI) of her head showed meningeal, cortical and subcortical enhancement that was new when compared to a study done prior to therapy. Subsequent imaging 10 days later showed partial resolution of these findings. The association of seizures and MTX in ALL and the corresponding MRI changes are discussed.

AB - A 27-year-old woman with acute lymphoblastic leukemia (ALL) had an episode of generalized tonicclonic seizure after therapy with intrathecal and intravenous methotrexate (MTX). Magnetic resonance imaging (MRI) of her head showed meningeal, cortical and subcortical enhancement that was new when compared to a study done prior to therapy. Subsequent imaging 10 days later showed partial resolution of these findings. The association of seizures and MTX in ALL and the corresponding MRI changes are discussed.

KW - Acute lymphocytic leukemia

KW - MRI

KW - Methotrexate

KW - Neurotoxicity

KW - Seizure

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JF - Leukemia and Lymphoma

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ER -

Methotrexate induced seizures associated with acute reversible magnetic resonance imaging (MRI) changes in a patient with acute lymphoblastic leukemia

Abstract

Keywords

ASJC Scopus subject areas

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