TY - JOUR
T1 - Methods for the assessment of small-bowel and colonic transit
AU - Szarka, Lawrence A.
AU - Camilleri, Michael
N1 - Funding Information:
The authors thank Mrs Cindy Stanislav for excellent secretarial support. M.C. is supported in part by grants RO1-DK-1RC1-DK086182 , R01-DK-079866 , and RO1-DK-67071 from National Institutes of Health .
PY - 2012/3
Y1 - 2012/3
N2 - Transit assessment of the small intestine and colon is relevant in the study of physiology, pathophysiology, and pharmacodynamics, and there is increasing use of small-bowel and colonic transit measurements in clinical practice as well. The main methods that are applied in clinical practice are substrate-hydrogen breath tests for small-bowel transit and radiopaque markers for colonic transit. Over the past 2-3 decades, scintigraphy has become the preferred standard in research studies, particularly for studies of pathophysiology and pharmacodynamics. New approaches include experimental stable isotope measurement of orocecal transit and the recently approved method using a wireless motility capsule that is validated as an accurate measurement of small-bowel and colonic transit.
AB - Transit assessment of the small intestine and colon is relevant in the study of physiology, pathophysiology, and pharmacodynamics, and there is increasing use of small-bowel and colonic transit measurements in clinical practice as well. The main methods that are applied in clinical practice are substrate-hydrogen breath tests for small-bowel transit and radiopaque markers for colonic transit. Over the past 2-3 decades, scintigraphy has become the preferred standard in research studies, particularly for studies of pathophysiology and pharmacodynamics. New approaches include experimental stable isotope measurement of orocecal transit and the recently approved method using a wireless motility capsule that is validated as an accurate measurement of small-bowel and colonic transit.
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U2 - 10.1053/j.semnuclmed.2011.10.004
DO - 10.1053/j.semnuclmed.2011.10.004
M3 - Review article
C2 - 22293166
AN - SCOPUS:84856408524
SN - 0001-2998
VL - 42
SP - 113
EP - 123
JO - Seminars in Nuclear Medicine
JF - Seminars in Nuclear Medicine
IS - 2
ER -