Metabolomics: A global biochemical approach to drug response and disease

Rima Kaddurah-Daouk, Bruce S. Kristal, Richard M Weinshilboum

Research output: Contribution to journalArticle

438 Citations (Scopus)

Abstract

Metabolomics is the study of metabolism at the global level. This rapidly developing new discipline has important potential implications for pharmacologic science. The concept that metabolic state is representative of the overall physiologic status of the organism lies at the heart of metabolomics. Metabolomic studies capture global biochemical events by assaying thousands of small molecules in cells, tissues, organs, or biological fluids - followed by the application of informatic techniques to define metabolomic signatures. Metabolomic studies can lead to enhanced understanding of disease mechanisms and to new diagnostic markers as well as enhanced understanding of mechanisms for drug or xenobiotic effect and increased ability to predict individual variation in drug response phenotypes (pharmacometabolomics). This review outlines the conceptual basis for metabolomics as well as analytical and informatic techniques used to study the metabolome and to define metabolomic signatures. It also highlights potential metabolomic applications to pharmacology and clinical pharmacology.

Original languageEnglish (US)
Pages (from-to)653-683
Number of pages31
JournalAnnual Review of Pharmacology and Toxicology
Volume48
DOIs
StatePublished - 2008

Fingerprint

Metabolomics
Pharmaceutical Preparations
Informatics
Metabolome
Clinical Pharmacology
Xenobiotics
Metabolism
Pharmacology
Tissue
Phenotype
Molecules
Fluids

Keywords

  • Electrochemical array detection
  • HPLC
  • Mass spectroscopy
  • Metabolomic signatures
  • NMR
  • Pharmacometabolomics

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

Metabolomics : A global biochemical approach to drug response and disease. / Kaddurah-Daouk, Rima; Kristal, Bruce S.; Weinshilboum, Richard M.

In: Annual Review of Pharmacology and Toxicology, Vol. 48, 2008, p. 653-683.

Research output: Contribution to journalArticle

@article{beddbd78411740a48ece97d5b8aac00f,
title = "Metabolomics: A global biochemical approach to drug response and disease",
abstract = "Metabolomics is the study of metabolism at the global level. This rapidly developing new discipline has important potential implications for pharmacologic science. The concept that metabolic state is representative of the overall physiologic status of the organism lies at the heart of metabolomics. Metabolomic studies capture global biochemical events by assaying thousands of small molecules in cells, tissues, organs, or biological fluids - followed by the application of informatic techniques to define metabolomic signatures. Metabolomic studies can lead to enhanced understanding of disease mechanisms and to new diagnostic markers as well as enhanced understanding of mechanisms for drug or xenobiotic effect and increased ability to predict individual variation in drug response phenotypes (pharmacometabolomics). This review outlines the conceptual basis for metabolomics as well as analytical and informatic techniques used to study the metabolome and to define metabolomic signatures. It also highlights potential metabolomic applications to pharmacology and clinical pharmacology.",
keywords = "Electrochemical array detection, HPLC, Mass spectroscopy, Metabolomic signatures, NMR, Pharmacometabolomics",
author = "Rima Kaddurah-Daouk and Kristal, {Bruce S.} and Weinshilboum, {Richard M}",
year = "2008",
doi = "10.1146/annurev.pharmtox.48.113006.094715",
language = "English (US)",
volume = "48",
pages = "653--683",
journal = "Annual Review of Pharmacology and Toxicology",
issn = "0362-1642",
publisher = "Annual Reviews Inc.",

}

TY - JOUR

T1 - Metabolomics

T2 - A global biochemical approach to drug response and disease

AU - Kaddurah-Daouk, Rima

AU - Kristal, Bruce S.

AU - Weinshilboum, Richard M

PY - 2008

Y1 - 2008

N2 - Metabolomics is the study of metabolism at the global level. This rapidly developing new discipline has important potential implications for pharmacologic science. The concept that metabolic state is representative of the overall physiologic status of the organism lies at the heart of metabolomics. Metabolomic studies capture global biochemical events by assaying thousands of small molecules in cells, tissues, organs, or biological fluids - followed by the application of informatic techniques to define metabolomic signatures. Metabolomic studies can lead to enhanced understanding of disease mechanisms and to new diagnostic markers as well as enhanced understanding of mechanisms for drug or xenobiotic effect and increased ability to predict individual variation in drug response phenotypes (pharmacometabolomics). This review outlines the conceptual basis for metabolomics as well as analytical and informatic techniques used to study the metabolome and to define metabolomic signatures. It also highlights potential metabolomic applications to pharmacology and clinical pharmacology.

AB - Metabolomics is the study of metabolism at the global level. This rapidly developing new discipline has important potential implications for pharmacologic science. The concept that metabolic state is representative of the overall physiologic status of the organism lies at the heart of metabolomics. Metabolomic studies capture global biochemical events by assaying thousands of small molecules in cells, tissues, organs, or biological fluids - followed by the application of informatic techniques to define metabolomic signatures. Metabolomic studies can lead to enhanced understanding of disease mechanisms and to new diagnostic markers as well as enhanced understanding of mechanisms for drug or xenobiotic effect and increased ability to predict individual variation in drug response phenotypes (pharmacometabolomics). This review outlines the conceptual basis for metabolomics as well as analytical and informatic techniques used to study the metabolome and to define metabolomic signatures. It also highlights potential metabolomic applications to pharmacology and clinical pharmacology.

KW - Electrochemical array detection

KW - HPLC

KW - Mass spectroscopy

KW - Metabolomic signatures

KW - NMR

KW - Pharmacometabolomics

UR - http://www.scopus.com/inward/record.url?scp=41149162296&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=41149162296&partnerID=8YFLogxK

U2 - 10.1146/annurev.pharmtox.48.113006.094715

DO - 10.1146/annurev.pharmtox.48.113006.094715

M3 - Article

C2 - 18184107

AN - SCOPUS:41149162296

VL - 48

SP - 653

EP - 683

JO - Annual Review of Pharmacology and Toxicology

JF - Annual Review of Pharmacology and Toxicology

SN - 0362-1642

ER -