Metabolism as a guiding force for immunity

Jonathan Jung, Hu Zeng, Tiffany Horng

Research output: Contribution to journalReview articlepeer-review

31 Scopus citations

Abstract

Recent studies indicate that cellular metabolism plays a key role in supporting immune cell maintenance and development. Here, we review how metabolism guides immune cell activation and differentiation to distinct cellular states, and how differential regulation of metabolism allows for context-dependent support during activation and lineage commitment. We discuss emerging principles of metabolic support of immune cell function in physiology and disease, as well as their general relevance to the field of cell biology.

Original languageEnglish (US)
Pages (from-to)85-93
Number of pages9
JournalNature Cell Biology
Volume21
Issue number1
DOIs
StatePublished - Jan 1 2019

ASJC Scopus subject areas

  • Cell Biology

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