TY - JOUR
T1 - Metabolic syndrome as a risk factor for barrett esophagus
T2 - A population-based case-control study
AU - Leggett, Cadman L.
AU - Nelsen, Eric M.
AU - Tian, Jianmin
AU - Schleck, Cathy B.
AU - Zinsmeister, Alan R.
AU - Dunagan, Kelly T.
AU - Locke, G. Richard
AU - Wang, Kenneth K.
AU - Talley, Nicholas J.
AU - Iyer, Prasad G.
N1 - Funding Information:
Grant Support: This study was supported by a Junior Faculty Development Award from the American College of Gastroenterology , the National Institute of Diabetes and Digestive and Kidney Diseases ( RC4DK090413 ), and the Mayo Foundation . Study data were obtained from the Rochester Epidemiology Project, which is supported by the National Institute on Aging of the National Institutes of Health under Award Number R01AG034676 ; Principal Investigators: Walter A. Rocca, MD, MPH, and Barbara P. Yawn, MD, MSc. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
PY - 2013/2
Y1 - 2013/2
N2 - Objectives: To assess the association between Barrett esophagus (BE) and the metabolic syndrome in patients with and without reflux symptoms and to determine whether this association is reflux independent and metabolically driven. Patients and Methods: Case patients with BE and controls were residents of Olmsted County, Minnesota (1999-2006). Two control groups (one with and one without symptoms of gastroesophageal reflux) were identified from a cohort of patients who had responded to a validated gastrointestinal symptom questionnaire. Cases and controls were individually matched by age, sex, and duration of follow-up. Controls did not have a known diagnosis of BE. The association of the metabolic syndrome and its individual components with BE was assessed using univariate and multivariate conditional logistic regression separately for each control group. Results: A total of 309 patients were included (103 BE cases, 103 controls with reflux symptoms, and 103 controls without reflux symptoms). A total of 64% of cases, 47% of controls with reflux symptoms, and 50% of controls without reflux symptoms had the metabolic syndrome. The metabolic syndrome was associated with a 2-fold increased risk of BE relative to those with (odds ratio, 2.00; 95% CI, 1.10-3.65; P=.02) and without (odds ratio, 1.90; 95% CI, 1.03-3.60; P=.04) reflux symptoms. This association was independent of smoking, alcohol consumption, and body mass index and remained robust with sensitivity analysis. Conclusion: The metabolic syndrome is associated with BE independent of reflux symptoms, which may reflect a reflux-independent pathway of BE pathogenesis.
AB - Objectives: To assess the association between Barrett esophagus (BE) and the metabolic syndrome in patients with and without reflux symptoms and to determine whether this association is reflux independent and metabolically driven. Patients and Methods: Case patients with BE and controls were residents of Olmsted County, Minnesota (1999-2006). Two control groups (one with and one without symptoms of gastroesophageal reflux) were identified from a cohort of patients who had responded to a validated gastrointestinal symptom questionnaire. Cases and controls were individually matched by age, sex, and duration of follow-up. Controls did not have a known diagnosis of BE. The association of the metabolic syndrome and its individual components with BE was assessed using univariate and multivariate conditional logistic regression separately for each control group. Results: A total of 309 patients were included (103 BE cases, 103 controls with reflux symptoms, and 103 controls without reflux symptoms). A total of 64% of cases, 47% of controls with reflux symptoms, and 50% of controls without reflux symptoms had the metabolic syndrome. The metabolic syndrome was associated with a 2-fold increased risk of BE relative to those with (odds ratio, 2.00; 95% CI, 1.10-3.65; P=.02) and without (odds ratio, 1.90; 95% CI, 1.03-3.60; P=.04) reflux symptoms. This association was independent of smoking, alcohol consumption, and body mass index and remained robust with sensitivity analysis. Conclusion: The metabolic syndrome is associated with BE independent of reflux symptoms, which may reflect a reflux-independent pathway of BE pathogenesis.
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U2 - 10.1016/j.mayocp.2012.09.017
DO - 10.1016/j.mayocp.2012.09.017
M3 - Article
C2 - 23374619
AN - SCOPUS:84876532762
SN - 0025-6196
VL - 88
SP - 157
EP - 165
JO - Mayo Clinic proceedings
JF - Mayo Clinic proceedings
IS - 2
ER -