TY - JOUR
T1 - Meta-analysis in more than 17,900 cases of ischemic stroke reveals a novel association at 12q24.12
AU - Kilarski, Laura L.
AU - Achterberg, Sefanja
AU - Devan, William J.
AU - Traylor, Matthew
AU - Malik, Rainer
AU - Lindgren, Arne
AU - Pare, Guillame
AU - Sharma, Pankaj
AU - Slowik, Agniesczka
AU - Thijs, Vincent
AU - Walters, Matthew
AU - Worrall, Bradford B.
AU - Sale, Michele M.
AU - Algra, Ale
AU - Kappelle, L. Jaap
AU - Wijmenga, Cisca
AU - Norrving, Bo
AU - Sandling, Johanna K.
AU - Rönnblom, Lars
AU - Goris, An
AU - Franke, Andre
AU - Sudlow, Cathie
AU - Rothwell, Peter M.
AU - Levi, Christopher
AU - Holliday, Elizabeth G.
AU - Fornage, Myriam
AU - Psaty, Bruce
AU - Gretarsdottir, Solveig
AU - Thorsteinsdottir, Unnar
AU - Seshadri, Sudha
AU - Mitchell, Braxton D.
AU - Kittner, Steven
AU - Clarke, Robert
AU - Hopewell, Jemma C.
AU - Bis, Joshua C.
AU - Boncoraglio, Giorgio B.
AU - Meschia, James
AU - Ikram, M. Arfan
AU - Hansen, Bjorn M.
AU - Montaner, Joan
AU - Thorleifsson, Gudmar
AU - Stefanson, Kari
AU - Rosand, Jonathan
AU - De Bakker, Paul I.W.
AU - Farrall, Martin
AU - Dichgans, Martin
AU - Markus, Hugh S.
AU - Bevan, Steve
N1 - Publisher Copyright:
© 2014 American Academy of Neurology.
PY - 2014/8/19
Y1 - 2014/8/19
N2 - Results: In an overall analysis of 17,970 cases of ischemic stroke and 70,764 controls, we identified a novel association on chromosome 12q24 (rs10744777, odds ratio [OR] 1.10 [1.07-1.13], p 5 7.12 3 10-11) with ischemic stroke. The association was with all ischemic stroke rather than an individual stroke subtype, with similar effect sizes seen in different stroke subtypes. There was no association with intracerebral hemorrhage (OR 1.03 [0.90-1.17], p 5 0.695).Conclusion: Our results show, for the first time, a genetic risk locus associated with ischemic stroke as a whole, rather than in a subtype-specific manner. This finding was not associated with intracerebral hemorrhage.Methods: Using the Immunochip, we genotyped 3,420 ischemic stroke cases and 6,821 controls. After imputation we meta-analyzed the results with imputed GWAS data from 3,548 cases and 5,972 controls recruited from the ischemic stroke WTCCC2 study, and with summary statistics from a further 8,480 cases and 56,032 controls in the METASTROKE consortium. A final in silico "look-up" of 2 single nucleotide polymorphisms in 2,522 cases and 1,899 controls was performed. Associations were also examined in 1,088 cases with intracerebral hemorrhage and 1,102 controls.Objectives: To perform a genome-wide association study (GWAS) using the Immunochip array in 3,420 cases of ischemic stroke and 6,821 controls, followed by a meta-analysis with data from more than 14,000 additional ischemic stroke cases.
AB - Results: In an overall analysis of 17,970 cases of ischemic stroke and 70,764 controls, we identified a novel association on chromosome 12q24 (rs10744777, odds ratio [OR] 1.10 [1.07-1.13], p 5 7.12 3 10-11) with ischemic stroke. The association was with all ischemic stroke rather than an individual stroke subtype, with similar effect sizes seen in different stroke subtypes. There was no association with intracerebral hemorrhage (OR 1.03 [0.90-1.17], p 5 0.695).Conclusion: Our results show, for the first time, a genetic risk locus associated with ischemic stroke as a whole, rather than in a subtype-specific manner. This finding was not associated with intracerebral hemorrhage.Methods: Using the Immunochip, we genotyped 3,420 ischemic stroke cases and 6,821 controls. After imputation we meta-analyzed the results with imputed GWAS data from 3,548 cases and 5,972 controls recruited from the ischemic stroke WTCCC2 study, and with summary statistics from a further 8,480 cases and 56,032 controls in the METASTROKE consortium. A final in silico "look-up" of 2 single nucleotide polymorphisms in 2,522 cases and 1,899 controls was performed. Associations were also examined in 1,088 cases with intracerebral hemorrhage and 1,102 controls.Objectives: To perform a genome-wide association study (GWAS) using the Immunochip array in 3,420 cases of ischemic stroke and 6,821 controls, followed by a meta-analysis with data from more than 14,000 additional ischemic stroke cases.
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U2 - 10.1212/WNL.0000000000000707
DO - 10.1212/WNL.0000000000000707
M3 - Article
C2 - 25031287
AN - SCOPUS:84920146738
SN - 0028-3878
VL - 83
SP - 678
EP - 685
JO - Neurology
JF - Neurology
IS - 8
ER -