Messenger RNA editing and the genetic code

Research output: Contribution to journalReview article

11 Scopus citations

Abstract

Messenger RNA editing is defined as a process leading to predetermined modifications of the coding region of a primary gene transcript. By this definition, splicing processes are special forms of editing; however, they are not dealt with in this review. Editing processes different from splicing have been defined in mammalian cells, in RNA viruses, and in mitochondria of trypanosomes, higher plants and vertebrates. These post- or co-transcriptional processes involve addition, deletion, or modification-substitution of nucleotides, and represent previously unrecognized mechanisms for altering the coding potential of a gene and for modulating gene expression.

Original languageEnglish (US)
Pages (from-to)1142-1148
Number of pages7
JournalExperientia
Volume46
Issue number11-12
DOIs
StatePublished - Dec 1 1990

Keywords

  • Apolipoprotein B
  • RNA modification
  • genetic code
  • messenger RNA editing
  • paramyxoviruses
  • plant mitochondria
  • trypanosome mitochondria
  • vertebrate mitochondria

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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