Mesenchymal stem cell-derived extracellular vesicles for renal repair

Arash Aghajani Nargesi, Lilach O Lerman, Alfonso Eirin

Research output: Contribution to journalReview article

38 Scopus citations

Abstract

Introduction: Transplantation of autologous mesenchymal stem cells (MSCs) has been shown to attenuate renal injury and dysfunction in several animal models, and its efficacy is currently being tested in clinical trials for patients with renal disease. Accumulating evidence indicates that MSCs release extracellular vesicles (EVs) that deliver genes, microRNAs and proteins to recipient cells, acting as mediators of MSC paracrine actions. In this context, it is critical to characterize the MSC-derived EV cargo to elucidate their potential contribution to renal repair. In recent years, researchers have performed high-throughput sequencing and proteomic analysis to detect and identify genes, microRNAs, and proteins enriched in MSC-derived EVs. Conclusion: The present review summarizes the current knowledge of the MSC-derived EV secretome to shed light into the mechanisms mediating MSC renal repair, and discusses preclinical and clinical studies testing the efficacy of MSC-derived EVs for treating renal disease.

Original languageEnglish (US)
Pages (from-to)29-42
Number of pages14
JournalCurrent Gene Therapy
Volume17
Issue number1
DOIs
StatePublished - Feb 1 2017

Keywords

  • Exosomes
  • Extracellular vesicles
  • Kidney
  • Mesenchymal stem cells
  • MicroRNA
  • Microvesicles

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Drug Discovery
  • Genetics(clinical)

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