TY - JOUR
T1 - Mesenchymal stem cell-derived extracellular vesicles for renal repair
AU - Nargesi, Arash Aghajani
AU - Lerman, Lilach O.
AU - Eirin, Alfonso
N1 - Funding Information:
This study was partly supported by NIHNational Institutes of Health grant numbers DK100081, DK104273, HL123160, DK102325, and DK106427, the Mayo Clinic Center for Regenerative Medicine, and the Mayo Clinic Foundation: Mary Kathryn and Michael B. Panitch Career Development Award.
Publisher Copyright:
© 2017 Bentham Science Publishers.
PY - 2017/2/1
Y1 - 2017/2/1
N2 - Introduction: Transplantation of autologous mesenchymal stem cells (MSCs) has been shown to attenuate renal injury and dysfunction in several animal models, and its efficacy is currently being tested in clinical trials for patients with renal disease. Accumulating evidence indicates that MSCs release extracellular vesicles (EVs) that deliver genes, microRNAs and proteins to recipient cells, acting as mediators of MSC paracrine actions. In this context, it is critical to characterize the MSC-derived EV cargo to elucidate their potential contribution to renal repair. In recent years, researchers have performed high-throughput sequencing and proteomic analysis to detect and identify genes, microRNAs, and proteins enriched in MSC-derived EVs. Conclusion: The present review summarizes the current knowledge of the MSC-derived EV secretome to shed light into the mechanisms mediating MSC renal repair, and discusses preclinical and clinical studies testing the efficacy of MSC-derived EVs for treating renal disease.
AB - Introduction: Transplantation of autologous mesenchymal stem cells (MSCs) has been shown to attenuate renal injury and dysfunction in several animal models, and its efficacy is currently being tested in clinical trials for patients with renal disease. Accumulating evidence indicates that MSCs release extracellular vesicles (EVs) that deliver genes, microRNAs and proteins to recipient cells, acting as mediators of MSC paracrine actions. In this context, it is critical to characterize the MSC-derived EV cargo to elucidate their potential contribution to renal repair. In recent years, researchers have performed high-throughput sequencing and proteomic analysis to detect and identify genes, microRNAs, and proteins enriched in MSC-derived EVs. Conclusion: The present review summarizes the current knowledge of the MSC-derived EV secretome to shed light into the mechanisms mediating MSC renal repair, and discusses preclinical and clinical studies testing the efficacy of MSC-derived EVs for treating renal disease.
KW - Exosomes
KW - Extracellular vesicles
KW - Kidney
KW - Mesenchymal stem cells
KW - MicroRNA
KW - Microvesicles
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U2 - 10.2174/1566523217666170412110724
DO - 10.2174/1566523217666170412110724
M3 - Review article
C2 - 28403795
AN - SCOPUS:85021266061
SN - 1566-5232
VL - 17
SP - 29
EP - 42
JO - Current Gene Therapy
JF - Current Gene Therapy
IS - 1
ER -