Meningitis

Allen J. Aksamit; Aaron L. Berkowitz

doi:10.1212/CON.0000000000001016

Meningitis

Allen J. Aksamit, Aaron L. Berkowitz

Neurology

Research output: Contribution to journal › Review article › peer-review

Abstract

PURPOSE OF REVIEW This article reviews the diagnosis and treatment of infectious meningitis, including updates on newer molecular diagnostic techniques for microbiological diagnosis. RECENT FINDINGS New polymerase chain reaction (PCR)-based molecular diagnostic techniques have improved the timeliness of microbiological diagnosis in meningitis, but clinicians must be aware of the limitations of such tests. Next-generation sequencing can now be applied to CSF, allowing for diagnosis of infections not identifiable by conventional means. SUMMARY Infectious meningitis can be caused by a broad range of organisms. The clinician must be aware of the test characteristics of new molecular techniques for microbiological diagnosis as well as traditional techniques to tailor antimicrobial therapy appropriately in patients with meningitis.

Original language	English (US)
Pages (from-to)	836-854
Number of pages	19
Journal	CONTINUUM Lifelong Learning in Neurology
Volume	27
Issue number	4
DOIs	https://doi.org/10.1212/CON.0000000000001016
State	Published - 2021

ASJC Scopus subject areas

Clinical Neurology
Genetics(clinical)

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10.1212/CON.0000000000001016

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title = "Meningitis",

abstract = "PURPOSE OF REVIEW This article reviews the diagnosis and treatment of infectious meningitis, including updates on newer molecular diagnostic techniques for microbiological diagnosis. RECENT FINDINGS New polymerase chain reaction (PCR)-based molecular diagnostic techniques have improved the timeliness of microbiological diagnosis in meningitis, but clinicians must be aware of the limitations of such tests. Next-generation sequencing can now be applied to CSF, allowing for diagnosis of infections not identifiable by conventional means. SUMMARY Infectious meningitis can be caused by a broad range of organisms. The clinician must be aware of the test characteristics of new molecular techniques for microbiological diagnosis as well as traditional techniques to tailor antimicrobial therapy appropriately in patients with meningitis.",

author = "Aksamit, {Allen J.} and Berkowitz, {Aaron L.}",

note = "Publisher Copyright: {\textcopyright} Lippincott Williams & Wilkins.",

year = "2021",

doi = "10.1212/CON.0000000000001016",

language = "English (US)",

volume = "27",

pages = "836--854",

journal = "CONTINUUM Lifelong Learning in Neurology",

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number = "4",

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T1 - Meningitis

AU - Aksamit, Allen J.

AU - Berkowitz, Aaron L.

N1 - Publisher Copyright: © Lippincott Williams & Wilkins.

PY - 2021

Y1 - 2021

N2 - PURPOSE OF REVIEW This article reviews the diagnosis and treatment of infectious meningitis, including updates on newer molecular diagnostic techniques for microbiological diagnosis. RECENT FINDINGS New polymerase chain reaction (PCR)-based molecular diagnostic techniques have improved the timeliness of microbiological diagnosis in meningitis, but clinicians must be aware of the limitations of such tests. Next-generation sequencing can now be applied to CSF, allowing for diagnosis of infections not identifiable by conventional means. SUMMARY Infectious meningitis can be caused by a broad range of organisms. The clinician must be aware of the test characteristics of new molecular techniques for microbiological diagnosis as well as traditional techniques to tailor antimicrobial therapy appropriately in patients with meningitis.

AB - PURPOSE OF REVIEW This article reviews the diagnosis and treatment of infectious meningitis, including updates on newer molecular diagnostic techniques for microbiological diagnosis. RECENT FINDINGS New polymerase chain reaction (PCR)-based molecular diagnostic techniques have improved the timeliness of microbiological diagnosis in meningitis, but clinicians must be aware of the limitations of such tests. Next-generation sequencing can now be applied to CSF, allowing for diagnosis of infections not identifiable by conventional means. SUMMARY Infectious meningitis can be caused by a broad range of organisms. The clinician must be aware of the test characteristics of new molecular techniques for microbiological diagnosis as well as traditional techniques to tailor antimicrobial therapy appropriately in patients with meningitis.

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M3 - Review article

C2 - 34623095

AN - SCOPUS:85112353320

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VL - 27

SP - 836

EP - 854

JO - CONTINUUM Lifelong Learning in Neurology

JF - CONTINUUM Lifelong Learning in Neurology

IS - 4

ER -

Meningitis

Abstract

ASJC Scopus subject areas

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