Meningioangiomatosis: an immunocytochemical study

J. J. Goates, Dennis W Dickson, D. S. Horoupian

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

Meningioangiomatosis (MA) is a rare malformative lesion of the central nervous system. It has generally been thought that the main cells forming this lesion are derived from arachnoidal cap cells. We report a case of MA in which histochemical, immunoperoxidase and electron microscopic studies did not support a meningothelial origin of this lesion. Rather, the lesion in this case appears to be a vascular malformation with the dominant cells being fibroblastic, derived from vessel walls; however, their origin from arachnoid cap cells that differentiated into fibroblast-like cells could not be totally ruled out. Residual neurons within the lesion contained neurofibrillary tangles with ultrastructural and immunostaining properties identical to those seen in Alzheimer's disease except for the absence of A4 amyloid.

Original languageEnglish (US)
Pages (from-to)527-532
Number of pages6
JournalActa Neuropathologica
Volume82
Issue number6
DOIs
StatePublished - Nov 1991
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Immunocytochemistry
  • Meningioangiomatosis
  • Neurofibrillary tangles
  • Vascular malformation

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pathology and Forensic Medicine
  • Clinical Neurology

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