Men are from mars, women are from venus: Sex differences in insulin action and secretion

Ananda Basu, Simmi Dube, Rita Basu

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Citations (Scopus)

Abstract

Sex difference plays a substantial role in the regulation of glucose metabolism in healthy glucose-tolerant humans. The factors which may contribute to the sex-related differences in glucose metabolism include differences in lifestyle (diet and exercise), sex hormones, and body composition. Several epidemiological and observational studies have noted that impaired glucose tolerance is more common in women than men. Some of these studies have attributed this to differences in body composition, while others have attributed impaired insulin sensitivity as a cause of impaired glucose tolerance in women. We studied postprandial glucose metabolism in 120 men and 90 women after ingestion of a mixed meal. Rates of meal glucose appearance, endogenous glucose production, and glucose disappearance were calculated using a novel triple-tracer isotope dilution method. Insulin action and secretion were calculated using validated physiological models. While rate of meal glucose appearance was higher in women than men, rates of glucose disappearance were higher in elderly women than elderly men while young women had lower rates of glucose disappearance than young men. Hence, sex has an impact on postprandial glucose metabolism, and sex differences in carbohydrate metabolism may have important implications for approaches to prevent and manage diabetes in an individual.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages53-64
Number of pages12
DOIs
StatePublished - Jan 1 2017
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1043
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Fingerprint

Venus
Mars
Sex Characteristics
Insulin
Glucose
Metabolism
Meals
Glucose Intolerance
Body Composition
Physiological models
Carbohydrate Metabolism
Gonadal Steroid Hormones
Isotopes
Observational Studies
Nutrition
Medical problems
Insulin Resistance
Life Style
Epidemiologic Studies
Chemical analysis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Basu, A., Dube, S., & Basu, R. (2017). Men are from mars, women are from venus: Sex differences in insulin action and secretion. In Advances in Experimental Medicine and Biology (pp. 53-64). (Advances in Experimental Medicine and Biology; Vol. 1043). Springer New York LLC. https://doi.org/10.1007/978-3-319-70178-3_4

Men are from mars, women are from venus : Sex differences in insulin action and secretion. / Basu, Ananda; Dube, Simmi; Basu, Rita.

Advances in Experimental Medicine and Biology. Springer New York LLC, 2017. p. 53-64 (Advances in Experimental Medicine and Biology; Vol. 1043).

Research output: Chapter in Book/Report/Conference proceedingChapter

Basu, A, Dube, S & Basu, R 2017, Men are from mars, women are from venus: Sex differences in insulin action and secretion. in Advances in Experimental Medicine and Biology. Advances in Experimental Medicine and Biology, vol. 1043, Springer New York LLC, pp. 53-64. https://doi.org/10.1007/978-3-319-70178-3_4
Basu A, Dube S, Basu R. Men are from mars, women are from venus: Sex differences in insulin action and secretion. In Advances in Experimental Medicine and Biology. Springer New York LLC. 2017. p. 53-64. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-3-319-70178-3_4
Basu, Ananda ; Dube, Simmi ; Basu, Rita. / Men are from mars, women are from venus : Sex differences in insulin action and secretion. Advances in Experimental Medicine and Biology. Springer New York LLC, 2017. pp. 53-64 (Advances in Experimental Medicine and Biology).
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