Abstract
Unraveling the genetic mechanisms of Fuchs endothelial corneal dystrophy has opened new possibilities for future targeted medical therapy of the disease. Until these possibilities mature, regenerative semi-surgical approaches by cell injection or cell sheet transfer could help expand the donor pool, and possibly enable autologous transplantation. Descemet membrane stripping alone and acellular Descemet membrane transfer are more immediate surgical approaches that could be temporary treatments in some patients, though there is a lack of understanding of the factors that predict success for these procedures. Regardless of approach, clinical trials will be necessary, and clinicians should therefore try to standardize their methods of assessing disease severity and the outcomes of intervention.
| Original language | German |
|---|---|
| Journal | Klinische Monatsblatter fur Augenheilkunde |
| DOIs | |
| State | Accepted/In press - May 3 2018 |
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Keywords
- cell injection
- endothelial keratoplasty
- Fuchs endothelial corneal dystrophy
- ROCK inhibitor
- TCF4 gene
- trinucleotide repeat expansion
ASJC Scopus subject areas
- Ophthalmology
Cite this
Interventionelle und pharmakologische Behandlungsansätze für Fuchs-Endotheldystrophie. / Wacker, Katrin; Baratz, Keith; Fautsch, Michael P; Patel, Sanjay V.
In: Klinische Monatsblatter fur Augenheilkunde, 03.05.2018.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Interventionelle und pharmakologische Behandlungsansätze für Fuchs-Endotheldystrophie
AU - Wacker, Katrin
AU - Baratz, Keith
AU - Fautsch, Michael P
AU - Patel, Sanjay V.
PY - 2018/5/3
Y1 - 2018/5/3
N2 - Unraveling the genetic mechanisms of Fuchs endothelial corneal dystrophy has opened new possibilities for future targeted medical therapy of the disease. Until these possibilities mature, regenerative semi-surgical approaches by cell injection or cell sheet transfer could help expand the donor pool, and possibly enable autologous transplantation. Descemet membrane stripping alone and acellular Descemet membrane transfer are more immediate surgical approaches that could be temporary treatments in some patients, though there is a lack of understanding of the factors that predict success for these procedures. Regardless of approach, clinical trials will be necessary, and clinicians should therefore try to standardize their methods of assessing disease severity and the outcomes of intervention.
AB - Unraveling the genetic mechanisms of Fuchs endothelial corneal dystrophy has opened new possibilities for future targeted medical therapy of the disease. Until these possibilities mature, regenerative semi-surgical approaches by cell injection or cell sheet transfer could help expand the donor pool, and possibly enable autologous transplantation. Descemet membrane stripping alone and acellular Descemet membrane transfer are more immediate surgical approaches that could be temporary treatments in some patients, though there is a lack of understanding of the factors that predict success for these procedures. Regardless of approach, clinical trials will be necessary, and clinicians should therefore try to standardize their methods of assessing disease severity and the outcomes of intervention.
KW - cell injection
KW - endothelial keratoplasty
KW - Fuchs endothelial corneal dystrophy
KW - ROCK inhibitor
KW - TCF4 gene
KW - trinucleotide repeat expansion
UR - http://www.scopus.com/inward/record.url?scp=85047345862&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85047345862&partnerID=8YFLogxK
U2 - 10.1055/a-0577-7953
DO - 10.1055/a-0577-7953
M3 - Article
C2 - 29723889
AN - SCOPUS:85047345862
JO - Klinische Monatsblatter fur Augenheilkunde
JF - Klinische Monatsblatter fur Augenheilkunde
SN - 0023-2165
ER -