Interventionelle und pharmakologische Behandlungsansätze für Fuchs-Endotheldystrophie

Translated title of the contribution: Medical and Semi-surgical Treatments for Fuchs Endothelial Corneal Dystrophy

Katrin Wacker, Keith Baratz, Michael P Fautsch, Sanjay V. Patel

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Unraveling the genetic mechanisms of Fuchs endothelial corneal dystrophy has opened new possibilities for future targeted medical therapy of the disease. Until these possibilities mature, regenerative semi-surgical approaches by cell injection or cell sheet transfer could help expand the donor pool, and possibly enable autologous transplantation. Descemet membrane stripping alone and acellular Descemet membrane transfer are more immediate surgical approaches that could be temporary treatments in some patients, though there is a lack of understanding of the factors that predict success for these procedures. Regardless of approach, clinical trials will be necessary, and clinicians should therefore try to standardize their methods of assessing disease severity and the outcomes of intervention.

Original languageGerman
JournalKlinische Monatsblatter fur Augenheilkunde
DOIs
StateAccepted/In press - May 3 2018

Fingerprint

Fuchs' Endothelial Dystrophy
Descemet Membrane
Autologous Transplantation
Tissue Donors
Clinical Trials
Injections
Therapeutics

Keywords

  • cell injection
  • endothelial keratoplasty
  • Fuchs endothelial corneal dystrophy
  • ROCK inhibitor
  • TCF4 gene
  • trinucleotide repeat expansion

ASJC Scopus subject areas

  • Ophthalmology

Cite this

@article{14e7668b96474c4b897c80e8c6c8900b,
title = "Interventionelle und pharmakologische Behandlungsans{\"a}tze f{\"u}r Fuchs-Endotheldystrophie",
abstract = "Unraveling the genetic mechanisms of Fuchs endothelial corneal dystrophy has opened new possibilities for future targeted medical therapy of the disease. Until these possibilities mature, regenerative semi-surgical approaches by cell injection or cell sheet transfer could help expand the donor pool, and possibly enable autologous transplantation. Descemet membrane stripping alone and acellular Descemet membrane transfer are more immediate surgical approaches that could be temporary treatments in some patients, though there is a lack of understanding of the factors that predict success for these procedures. Regardless of approach, clinical trials will be necessary, and clinicians should therefore try to standardize their methods of assessing disease severity and the outcomes of intervention.",
keywords = "cell injection, endothelial keratoplasty, Fuchs endothelial corneal dystrophy, ROCK inhibitor, TCF4 gene, trinucleotide repeat expansion",
author = "Katrin Wacker and Keith Baratz and Fautsch, {Michael P} and Patel, {Sanjay V.}",
year = "2018",
month = "5",
day = "3",
doi = "10.1055/a-0577-7953",
language = "German",
journal = "Klinische Monatsblatter fur Augenheilkunde",
issn = "0023-2165",
publisher = "Ferdinand Enke Verlag",

}

TY - JOUR

T1 - Interventionelle und pharmakologische Behandlungsansätze für Fuchs-Endotheldystrophie

AU - Wacker, Katrin

AU - Baratz, Keith

AU - Fautsch, Michael P

AU - Patel, Sanjay V.

PY - 2018/5/3

Y1 - 2018/5/3

N2 - Unraveling the genetic mechanisms of Fuchs endothelial corneal dystrophy has opened new possibilities for future targeted medical therapy of the disease. Until these possibilities mature, regenerative semi-surgical approaches by cell injection or cell sheet transfer could help expand the donor pool, and possibly enable autologous transplantation. Descemet membrane stripping alone and acellular Descemet membrane transfer are more immediate surgical approaches that could be temporary treatments in some patients, though there is a lack of understanding of the factors that predict success for these procedures. Regardless of approach, clinical trials will be necessary, and clinicians should therefore try to standardize their methods of assessing disease severity and the outcomes of intervention.

AB - Unraveling the genetic mechanisms of Fuchs endothelial corneal dystrophy has opened new possibilities for future targeted medical therapy of the disease. Until these possibilities mature, regenerative semi-surgical approaches by cell injection or cell sheet transfer could help expand the donor pool, and possibly enable autologous transplantation. Descemet membrane stripping alone and acellular Descemet membrane transfer are more immediate surgical approaches that could be temporary treatments in some patients, though there is a lack of understanding of the factors that predict success for these procedures. Regardless of approach, clinical trials will be necessary, and clinicians should therefore try to standardize their methods of assessing disease severity and the outcomes of intervention.

KW - cell injection

KW - endothelial keratoplasty

KW - Fuchs endothelial corneal dystrophy

KW - ROCK inhibitor

KW - TCF4 gene

KW - trinucleotide repeat expansion

UR - http://www.scopus.com/inward/record.url?scp=85047345862&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85047345862&partnerID=8YFLogxK

U2 - 10.1055/a-0577-7953

DO - 10.1055/a-0577-7953

M3 - Article

C2 - 29723889

AN - SCOPUS:85047345862

JO - Klinische Monatsblatter fur Augenheilkunde

JF - Klinische Monatsblatter fur Augenheilkunde

SN - 0023-2165

ER -