Mechanobiological feedback in pulmonary vascular disease

Paul B. Dieffenbach, Marcy Maracle, Daniel J Tschumperlin, Laura E. Fredenburgh

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Vascular stiffening in the pulmonary arterial bed is increasingly recognized as an early disease marker and contributor to right ventricular workload in pulmonary hypertension. Changes in pulmonary artery stiffness throughout the pulmonary vascular tree lead to physiologic alterations in pressure and flow characteristics that may contribute to disease progression. These findings have led to a greater focus on the potential contributions of extracellular matrix remodeling and mechanical signaling to pulmonary hypertension pathogenesis. Several recent studies have demonstrated that the cellular response to vascular stiffness includes upregulation of signaling pathways that precipitate further vascular remodeling, a process known as mechanobiological feedback. The extracellular matrix modifiers, mechanosensors, and mechanotransducers responsible for this process have become increasingly well-recognized. In this review, we discuss the impact of vascular stiffening on pulmonary hypertension morbidity and mortality, evidence in favor of mechanobiological feedback in pulmonary hypertension pathogenesis, and the major contributors to mechanical signaling in the pulmonary vasculature.

Original languageEnglish (US)
Article number951
JournalFrontiers in Physiology
Volume9
Issue numberJUL
DOIs
StatePublished - Jul 25 2018

Fingerprint

Vascular Diseases
Pulmonary Hypertension
Lung Diseases
Blood Vessels
Lung
Extracellular Matrix
Vascular Stiffness
Workload
Pulmonary Artery
Disease Progression
Up-Regulation
Morbidity
Pressure
Mortality

Keywords

  • Cellular mechanosensors
  • Matrix stiffness
  • Mechanotransduction
  • Pulmonary arterial stiffness
  • Pulmonary hypertension
  • Vascular remodeling
  • Vascular stiffness
  • YAP/TAZ

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Mechanobiological feedback in pulmonary vascular disease. / Dieffenbach, Paul B.; Maracle, Marcy; Tschumperlin, Daniel J; Fredenburgh, Laura E.

In: Frontiers in Physiology, Vol. 9, No. JUL, 951, 25.07.2018.

Research output: Contribution to journalReview article

Dieffenbach, Paul B. ; Maracle, Marcy ; Tschumperlin, Daniel J ; Fredenburgh, Laura E. / Mechanobiological feedback in pulmonary vascular disease. In: Frontiers in Physiology. 2018 ; Vol. 9, No. JUL.
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