Mechanisms of recruitment in oleic acid-injured lungs

Marek A. Martynowicz, Bruce J. Walters, Rolf D. Hubmayr

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

Mechanisms of recruitment in oleic acid-injured lungs. J Appl Physiol 90: 1744-1753, 2001. - Lung recruitment strategies, such as the application of positive end-expiratory pressure (PEEP), are thought to protect the lungs from ventilator-associated injury by reducing the shear stress associated with the repeated opening of collapsed peripheral units. Using the parenchymal marker technique, we measured regional lung deformations in 13 oleic acid (OA)-injured dogs during mechanical ventilation in different postures. Whereas OA injury caused a marked decrease in the oscillation amplitude of dependent lung regions, even the most dependent regions maintained normal end-expiratory dimensions. This is because dependent lung is flooded as opposed to collapsed. PEEP restored oscillation amplitudes only at pressures that raised regional volumes above preinjury levels. Because the amount of PEEP necessary to promote dependent lung recruitment increased the endexpiratory dimensions of all lung regions (nondependent AND dependent ones) compared with their preinjury baseline, the "price" for recruitment is a universal increase in parenchymal stress. We conclude that the mechanics of the OAinjured lung might be more appropriately viewed as a partial liquid ventilation problem and not a shear stress and airway collapse problem and that the mechanisms of PEEP-related lung protection might have to be rethought.

Original languageEnglish (US)
Pages (from-to)1744-1753
Number of pages10
JournalJournal of Applied Physiology
Volume90
Issue number5
StatePublished - 2001

Fingerprint

Oleic Acid
Lung
Positive-Pressure Respiration
Liquid Ventilation
Wounds and Injuries
Mechanical Ventilators
Mechanics
Posture
Artificial Respiration
Dogs
Pressure

Keywords

  • Anesthetized dogs
  • Lung mechanics
  • Mechanical ventilation
  • Positive end-expiratory pressure
  • Posture

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Martynowicz, M. A., Walters, B. J., & Hubmayr, R. D. (2001). Mechanisms of recruitment in oleic acid-injured lungs. Journal of Applied Physiology, 90(5), 1744-1753.

Mechanisms of recruitment in oleic acid-injured lungs. / Martynowicz, Marek A.; Walters, Bruce J.; Hubmayr, Rolf D.

In: Journal of Applied Physiology, Vol. 90, No. 5, 2001, p. 1744-1753.

Research output: Contribution to journalArticle

Martynowicz, MA, Walters, BJ & Hubmayr, RD 2001, 'Mechanisms of recruitment in oleic acid-injured lungs', Journal of Applied Physiology, vol. 90, no. 5, pp. 1744-1753.
Martynowicz MA, Walters BJ, Hubmayr RD. Mechanisms of recruitment in oleic acid-injured lungs. Journal of Applied Physiology. 2001;90(5):1744-1753.
Martynowicz, Marek A. ; Walters, Bruce J. ; Hubmayr, Rolf D. / Mechanisms of recruitment in oleic acid-injured lungs. In: Journal of Applied Physiology. 2001 ; Vol. 90, No. 5. pp. 1744-1753.
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