TY - JOUR
T1 - Mechanisms of hypoandrogenemia in healthy aging men
AU - Liu, Peter Y.
AU - Iranmanesh, Ali
AU - Nehra, Ajay X.
AU - Keenan, Daniel M.
AU - Veldhuis, Johannes D.
N1 - Funding Information:
Dr. Liu was supported by fellowships from the National Health and Medical Research Council of Australia (grant ID 262025) and Royal Australasian College of Physicians. Support was provided by Grants K01 AG19164 and R01 AG23133 from the National Institutes of Health (Bethesda, MD); DMS-0107680, a National Science Foundation Interdisciplinary Grant in the Mathematical Sciences (Washington, DC); and M01 RR00585 from the National Center for Research Resources.
PY - 2005/12
Y1 - 2005/12
N2 - Androgen deprivation adversely impacts libido and sexual potency, psychologic well being, mood and (possibly) cognition, exercise tolerance, muscle mass, bone mineral density, intra-abdominal adiposity, and lipid and carbohydrate metabolism [32,34]. Collective data identify presumptive impairment of hypothalamic GnRH outflow, reduction in pulsatile LH-stimulated testosterone synthesis, and decreased negative feedback in older men. Understanding the primary mechanistic bases of testosterone depletion in aging men may foster novel therapeutic strategies to maintain anabolism, enhance quality of life, and minimize physical frailty.
AB - Androgen deprivation adversely impacts libido and sexual potency, psychologic well being, mood and (possibly) cognition, exercise tolerance, muscle mass, bone mineral density, intra-abdominal adiposity, and lipid and carbohydrate metabolism [32,34]. Collective data identify presumptive impairment of hypothalamic GnRH outflow, reduction in pulsatile LH-stimulated testosterone synthesis, and decreased negative feedback in older men. Understanding the primary mechanistic bases of testosterone depletion in aging men may foster novel therapeutic strategies to maintain anabolism, enhance quality of life, and minimize physical frailty.
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U2 - 10.1016/j.ecl.2005.07.008
DO - 10.1016/j.ecl.2005.07.008
M3 - Review article
C2 - 16310632
AN - SCOPUS:27944460951
SN - 0889-8529
VL - 34
SP - 935
EP - 955
JO - Endocrinology and Metabolism Clinics of North America
JF - Endocrinology and Metabolism Clinics of North America
IS - 4
ER -