Mechanisms of hypoandrogenemia in healthy aging men

Peter Y. Liu, Ali Iranmanesh, Ajay X. Nehra, Daniel M. Keenan, Johannes D Veldhuis

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Androgen deprivation adversely impacts libido and sexual potency, psychologic well being, mood and (possibly) cognition, exercise tolerance, muscle mass, bone mineral density, intra-abdominal adiposity, and lipid and carbohydrate metabolism [32,34]. Collective data identify presumptive impairment of hypothalamic GnRH outflow, reduction in pulsatile LH-stimulated testosterone synthesis, and decreased negative feedback in older men. Understanding the primary mechanistic bases of testosterone depletion in aging men may foster novel therapeutic strategies to maintain anabolism, enhance quality of life, and minimize physical frailty.

Original languageEnglish (US)
Pages (from-to)935-955
Number of pages21
JournalEndocrinology and Metabolism Clinics of North America
Volume34
Issue number4
DOIs
StatePublished - Dec 2005

Fingerprint

Testosterone
Aging of materials
Libido
Exercise Tolerance
Adiposity
Carbohydrate Metabolism
Lipid Metabolism
Gonadotropin-Releasing Hormone
Bone Density
Cognition
Androgens
Minerals
Muscle
Bone
Quality of Life
Feedback
Muscles
Therapeutics

ASJC Scopus subject areas

  • Endocrinology
  • Biochemistry

Cite this

Liu, P. Y., Iranmanesh, A., Nehra, A. X., Keenan, D. M., & Veldhuis, J. D. (2005). Mechanisms of hypoandrogenemia in healthy aging men. Endocrinology and Metabolism Clinics of North America, 34(4), 935-955. https://doi.org/10.1016/j.ecl.2005.07.008

Mechanisms of hypoandrogenemia in healthy aging men. / Liu, Peter Y.; Iranmanesh, Ali; Nehra, Ajay X.; Keenan, Daniel M.; Veldhuis, Johannes D.

In: Endocrinology and Metabolism Clinics of North America, Vol. 34, No. 4, 12.2005, p. 935-955.

Research output: Contribution to journalArticle

Liu, PY, Iranmanesh, A, Nehra, AX, Keenan, DM & Veldhuis, JD 2005, 'Mechanisms of hypoandrogenemia in healthy aging men', Endocrinology and Metabolism Clinics of North America, vol. 34, no. 4, pp. 935-955. https://doi.org/10.1016/j.ecl.2005.07.008
Liu, Peter Y. ; Iranmanesh, Ali ; Nehra, Ajay X. ; Keenan, Daniel M. ; Veldhuis, Johannes D. / Mechanisms of hypoandrogenemia in healthy aging men. In: Endocrinology and Metabolism Clinics of North America. 2005 ; Vol. 34, No. 4. pp. 935-955.
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