Mechanisms of hypoandrogenemia in healthy aging men

Peter Y. Liu, Ali Iranmanesh, Ajay X. Nehra, Daniel M. Keenan, Johannes D. Veldhuis

Research output: Contribution to journalReview article

22 Scopus citations

Abstract

Androgen deprivation adversely impacts libido and sexual potency, psychologic well being, mood and (possibly) cognition, exercise tolerance, muscle mass, bone mineral density, intra-abdominal adiposity, and lipid and carbohydrate metabolism [32,34]. Collective data identify presumptive impairment of hypothalamic GnRH outflow, reduction in pulsatile LH-stimulated testosterone synthesis, and decreased negative feedback in older men. Understanding the primary mechanistic bases of testosterone depletion in aging men may foster novel therapeutic strategies to maintain anabolism, enhance quality of life, and minimize physical frailty.

Original languageEnglish (US)
Pages (from-to)935-955
Number of pages21
JournalEndocrinology and Metabolism Clinics of North America
Volume34
Issue number4
DOIs
StatePublished - Dec 2005

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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    Liu, P. Y., Iranmanesh, A., Nehra, A. X., Keenan, D. M., & Veldhuis, J. D. (2005). Mechanisms of hypoandrogenemia in healthy aging men. Endocrinology and Metabolism Clinics of North America, 34(4), 935-955. https://doi.org/10.1016/j.ecl.2005.07.008