Mechanisms driving the ageing heart

Rhys Anderson, Gavin D. Richardson, João F. Passos

Research output: Contribution to journalReview article

10 Scopus citations

Abstract

Cardiovascular disease (CVD) is the leading cause of death globally. One of the main risk factors for CVD is age, however the biological processes that occur in the heart during ageing are poorly understood. It is therefore important to understand the fundamental mechanisms driving heart ageing to enable the development of preventions and treatments targeting these processes. Cellular senescence is often described as the irreversible cell-cycle arrest which occurs in somatic cells. Emerging evidence suggests that cellular senescence plays a key role in heart ageing, however the cell-types involved and the underlying mechanisms are not yet elucidated. In this review we discuss the current understanding of how mechanisms known to contribute to senescence impact on heart ageing and CVD. Finally, we evaluate recent data suggesting that targeting senescent cells may be a viable therapy to counteract the ageing of the heart.

Original languageEnglish (US)
Pages (from-to)5-15
Number of pages11
JournalExperimental Gerontology
Volume109
DOIs
StatePublished - Aug 2018

Keywords

  • DNA damage response
  • Mitochondria
  • Reactive oxygen species
  • Senescence
  • Telomeres

ASJC Scopus subject areas

  • Biochemistry
  • Aging
  • Molecular Biology
  • Genetics
  • Endocrinology
  • Cell Biology

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