Mechanisms and metabolic implications of regional differences among fat depots

Tamara Tchkonia, Thomas Thomou, Yi Zhu, Iordanes Karagiannides, Charalabos Pothoulakis, Michael Dennis Jensen, James L Kirkland

Research output: Contribution to journalArticle

241 Citations (Scopus)

Abstract

Fat distribution is closely linked to metabolic disease risk. Distribution varies with sex, genetic background, disease state, certain drugs and hormones, development, and aging. Preadipocyte replication and differentiation, developmental gene expression, susceptibility to apoptosis and cellular senescence, vascularity, inflammatory cell infiltration, and adipokine secretion vary among depots, as do fatty-acid handling and mechanisms of enlargement with positive-energy and loss with negative-energy balance. How interdepot differences in these molecular, cellular, and pathophysiological properties are related is incompletely understood. Whether fat redistribution causes metabolic disease or whether it is a marker of underlying processes that are primarily responsible is an open question.

Original languageEnglish (US)
Pages (from-to)644-656
Number of pages13
JournalCell Metabolism
Volume17
Issue number5
DOIs
StatePublished - May 7 2013

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Metabolic Diseases
Fats
Developmental Genes
Inborn Genetic Diseases
Adipokines
Cell Aging
Fatty Acids
Hormones
Apoptosis
Gene Expression
Pharmaceutical Preparations
Genetic Background

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Physiology

Cite this

Mechanisms and metabolic implications of regional differences among fat depots. / Tchkonia, Tamara; Thomou, Thomas; Zhu, Yi; Karagiannides, Iordanes; Pothoulakis, Charalabos; Jensen, Michael Dennis; Kirkland, James L.

In: Cell Metabolism, Vol. 17, No. 5, 07.05.2013, p. 644-656.

Research output: Contribution to journalArticle

Tchkonia, Tamara ; Thomou, Thomas ; Zhu, Yi ; Karagiannides, Iordanes ; Pothoulakis, Charalabos ; Jensen, Michael Dennis ; Kirkland, James L. / Mechanisms and metabolic implications of regional differences among fat depots. In: Cell Metabolism. 2013 ; Vol. 17, No. 5. pp. 644-656.
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