TY - JOUR
T1 - Mechanism of immunomodulatory drugs' action in the treatment of multiple myeloma
AU - Chang, Xiubao
AU - Zhu, Yuanxiao
AU - Shi, Changxin
AU - Stewart, A. Keith
PY - 2014/3
Y1 - 2014/3
N2 - Although immunomodulatory drugs (IMiDs), such as thalidomide, lenalidomide, and pomalidomide, are widely used in the treatment of multiple myeloma (MM), the molecular mechanism of IMiDs' action is largely unknown. In this review, we will summarize recent advances in the application of IMiDs in MM cancer treatment as well as their effects on immunomodulatory activities, anti-angiogenic activities, intervention of cell surface adhesion molecules between myeloma cells and bone marrow stromal cells, anti-inflammatory activities, anti-proliferation, pro-apoptotic effects, cell cycle arrest, and inhibition of cell migration and metastasis. In addition, the potential IMiDs' target protein, IMiDs' target protein's functional role, and the potential molecular mechanisms of IMiDs resistance will be discussed. We wish, by presentation of our naive discussion, that this review article will facilitate further investigation in these fields.
AB - Although immunomodulatory drugs (IMiDs), such as thalidomide, lenalidomide, and pomalidomide, are widely used in the treatment of multiple myeloma (MM), the molecular mechanism of IMiDs' action is largely unknown. In this review, we will summarize recent advances in the application of IMiDs in MM cancer treatment as well as their effects on immunomodulatory activities, anti-angiogenic activities, intervention of cell surface adhesion molecules between myeloma cells and bone marrow stromal cells, anti-inflammatory activities, anti-proliferation, pro-apoptotic effects, cell cycle arrest, and inhibition of cell migration and metastasis. In addition, the potential IMiDs' target protein, IMiDs' target protein's functional role, and the potential molecular mechanisms of IMiDs resistance will be discussed. We wish, by presentation of our naive discussion, that this review article will facilitate further investigation in these fields.
KW - E3 ubiquitin ligase
KW - cancer treatment
KW - cereblon
KW - immunomodulatory drugs
KW - multiple myeloma
UR - http://www.scopus.com/inward/record.url?scp=84897722338&partnerID=8YFLogxK
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U2 - 10.1093/abbs/gmt142
DO - 10.1093/abbs/gmt142
M3 - Review article
C2 - 24374776
AN - SCOPUS:84897722338
SN - 1672-9145
VL - 46
SP - 240
EP - 253
JO - Acta Biochimica et Biophysica Sinica
JF - Acta Biochimica et Biophysica Sinica
IS - 3
ER -