Mechanical properties of a biodegradable bone regeneration scaffold

B. D. Porter, J. B. Oldham, S. L. He, M. E. Zobitz, R. G. Payne, K. N. An, B. L. Currier, A. G. Mikos, M. J. Yaszemski

Research output: Contribution to journalArticle

69 Scopus citations

Abstract

Poly (Propylene Fumarate) (PPF), a novel, bulk erosion, biode- gradable polymer, has been shown to have osteoconductive effects in vivo when used as a bone regeneration scaffold (Peter, S. J., Suggs, L. J., Yaszemski, M. J., Engel, P. S., and Mikos, A. J., 1999, J. Biomater. Sci. Polym. Ed., 10, pp. 363-373). The material properties of the polymer allow it to be injected into irregularly shaped voids in vivo and provide mechanical stability as well as function as a bone regeneration scaffold. We fabricated a series of biomaterial composites, comprised of varying quantities of PPF, NaCl and β- tricalcium phosphate (β-TCP), into the shape of right circular cylinders and tested the mechanical properties in four-point bending and compression. The mean modulus of elasticity in compression (E(c)) was 1204.2 MPa (SD 32.2) and the mean modulus of elasticity in bending (E(b)) was 1274.7 MPa (SD 125.7). All of the moduli were on the order of magnitude of trabecular bone. Changing the level of NaCl from 20 to 40 percent, by mass, did not decrease E(c) and E(b) significantly, but did decrease bending and compressive strength significantly. Increasing the β-TCP from 0.25 g/g PPF to 0.5 g/g PPF increased all of the measured mechanical properties of PPF/NVP composites. These results indicate that this biodegradable polymer composite is an attractive candidate for use as a replacement scaffold for trabecular bone.

Original languageEnglish (US)
Pages (from-to)286-288
Number of pages3
JournalJournal of Biomechanical Engineering
Volume122
Issue number3
DOIs
StatePublished - Jun 1 2000

Keywords

  • Biodegradable Polymers
  • Bone Regeneration
  • Mechanical Strength
  • Tissue Engineering

ASJC Scopus subject areas

  • Biomedical Engineering
  • Physiology (medical)

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    Porter, B. D., Oldham, J. B., He, S. L., Zobitz, M. E., Payne, R. G., An, K. N., Currier, B. L., Mikos, A. G., & Yaszemski, M. J. (2000). Mechanical properties of a biodegradable bone regeneration scaffold. Journal of Biomechanical Engineering, 122(3), 286-288. https://doi.org/10.1115/1.429659