Mechanical closure devices for atrial fibrillation

Matthew J. Price, David Holmes

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Atrial fibrillation (AF) is the most commonly sustained arrhythmia and is a major cause of stroke and systemic embolism. Chronic oral anticoagulation reduces this risk, but at the cost of increased bleeding. In addition, a substantial proportion of AF patients who are at moderate-to-high risk for stroke are undertreated due to real or perceived contraindications. The major source of thromboembolism in AF appears to be the left atrial appendage (LAA). Therefore, device closure of the LAA represents a mechanical approach to stroke prevention in AF patients. In this review, we describe the rationale for device closure of the LAA, summarize the current dataset for LAA closure devices, and set forth a framework to help guide patient selection for device therapy.

Original languageEnglish (US)
Pages (from-to)225-231
Number of pages7
JournalTrends in cardiovascular medicine
Volume24
Issue number6
DOIs
StatePublished - Aug 1 2014
Externally publishedYes

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Atrial Appendage
Atrial Fibrillation
Equipment and Supplies
Stroke
Thromboembolism
Embolism
Patient Selection
Cardiac Arrhythmias
Hemorrhage
Therapeutics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Mechanical closure devices for atrial fibrillation. / Price, Matthew J.; Holmes, David.

In: Trends in cardiovascular medicine, Vol. 24, No. 6, 01.08.2014, p. 225-231.

Research output: Contribution to journalReview article

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