Measurement of muscle activity with magnetic resonance elastography

Guido Heers, Thomas Jenkyn, M. Alex Dresner, Marc Oliver Klein, Jeffrey R. Basford, Kenton R Kaufman, Richard Lorne Ehman, Kai Nan An

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Objective. To non-invasively determine muscle activity. Design. A correlation analysis study. Background. Electromyography is traditionally used to measure the electrical activity of a muscle and can be used to estimate muscle contraction intensity. This approach, however, is limited not only in terms of the volume of tissue that can be monitored, but must be invasive if deep lying muscles are studied. We wished to avoid these limitations and used magnetic resonance elastography in an attempt to non-invasively determine muscle activity. This novel approach uses a conventional MRI system. However, in addition to the imaging gradients, an oscillating, motion sensitizing field gradient is applied to detect mechanical waves that have been generated within the tissue. The wavelength correlates with the stiffness of the muscle and hence with the activity of the muscle. Methods. Six volunteers (mean age: 30.1 years, range: 27-36 years) without orthopedic or neuromuscular abnormalities, lay supine with their legs within the coil of a MRI scanner. The wavelengths of mechanically generated shear waves in the tibialis anterior, medial and lateral head of the gastrocnemius and the soleus were measured as the subjects resisted ankle plantar-flexing (8.2 and 16.4 nm) and dorsi-flexing (20.2 and 40.4 nm) moments. The findings were then compared to EMG data collected under the same loading conditions. Results. Magnetic resonance elastography wavelengths were linearly correlated to the muscular activity as defined by electromyography. (TA, R2=0.89, P=0.02; MG, R2=0.82, P=0.05; LG, R2=0.88, P=0.03; S, R2=0.90, P=0.02) Conclusions. Magnetic resonance elastography may be a promising tool for the non-invasive determination of muscle activity. Relevance. Magnetic resonance elastography has potential as the basis for a new non-invasive approach to study in vivo muscle function.

Original languageEnglish (US)
Pages (from-to)537-542
Number of pages6
JournalClinical Biomechanics
Volume18
Issue number6
DOIs
StatePublished - Jul 2003

Fingerprint

Elasticity Imaging Techniques
Muscles
Electromyography
Muscle Contraction
Ankle
Orthopedics
Volunteers
Leg

Keywords

  • EMG
  • Magnetic resonance elastography
  • Material properties
  • MRI
  • Muscle
  • Muscle contraction
  • Strength

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

Cite this

Heers, G., Jenkyn, T., Alex Dresner, M., Klein, M. O., Basford, J. R., Kaufman, K. R., ... An, K. N. (2003). Measurement of muscle activity with magnetic resonance elastography. Clinical Biomechanics, 18(6), 537-542. https://doi.org/10.1016/S0268-0033(03)00070-6

Measurement of muscle activity with magnetic resonance elastography. / Heers, Guido; Jenkyn, Thomas; Alex Dresner, M.; Klein, Marc Oliver; Basford, Jeffrey R.; Kaufman, Kenton R; Ehman, Richard Lorne; An, Kai Nan.

In: Clinical Biomechanics, Vol. 18, No. 6, 07.2003, p. 537-542.

Research output: Contribution to journalArticle

Heers, G, Jenkyn, T, Alex Dresner, M, Klein, MO, Basford, JR, Kaufman, KR, Ehman, RL & An, KN 2003, 'Measurement of muscle activity with magnetic resonance elastography', Clinical Biomechanics, vol. 18, no. 6, pp. 537-542. https://doi.org/10.1016/S0268-0033(03)00070-6
Heers, Guido ; Jenkyn, Thomas ; Alex Dresner, M. ; Klein, Marc Oliver ; Basford, Jeffrey R. ; Kaufman, Kenton R ; Ehman, Richard Lorne ; An, Kai Nan. / Measurement of muscle activity with magnetic resonance elastography. In: Clinical Biomechanics. 2003 ; Vol. 18, No. 6. pp. 537-542.
@article{1d1e559c59744f80bdd2adc226cf589b,
title = "Measurement of muscle activity with magnetic resonance elastography",
abstract = "Objective. To non-invasively determine muscle activity. Design. A correlation analysis study. Background. Electromyography is traditionally used to measure the electrical activity of a muscle and can be used to estimate muscle contraction intensity. This approach, however, is limited not only in terms of the volume of tissue that can be monitored, but must be invasive if deep lying muscles are studied. We wished to avoid these limitations and used magnetic resonance elastography in an attempt to non-invasively determine muscle activity. This novel approach uses a conventional MRI system. However, in addition to the imaging gradients, an oscillating, motion sensitizing field gradient is applied to detect mechanical waves that have been generated within the tissue. The wavelength correlates with the stiffness of the muscle and hence with the activity of the muscle. Methods. Six volunteers (mean age: 30.1 years, range: 27-36 years) without orthopedic or neuromuscular abnormalities, lay supine with their legs within the coil of a MRI scanner. The wavelengths of mechanically generated shear waves in the tibialis anterior, medial and lateral head of the gastrocnemius and the soleus were measured as the subjects resisted ankle plantar-flexing (8.2 and 16.4 nm) and dorsi-flexing (20.2 and 40.4 nm) moments. The findings were then compared to EMG data collected under the same loading conditions. Results. Magnetic resonance elastography wavelengths were linearly correlated to the muscular activity as defined by electromyography. (TA, R2=0.89, P=0.02; MG, R2=0.82, P=0.05; LG, R2=0.88, P=0.03; S, R2=0.90, P=0.02) Conclusions. Magnetic resonance elastography may be a promising tool for the non-invasive determination of muscle activity. Relevance. Magnetic resonance elastography has potential as the basis for a new non-invasive approach to study in vivo muscle function.",
keywords = "EMG, Magnetic resonance elastography, Material properties, MRI, Muscle, Muscle contraction, Strength",
author = "Guido Heers and Thomas Jenkyn and {Alex Dresner}, M. and Klein, {Marc Oliver} and Basford, {Jeffrey R.} and Kaufman, {Kenton R} and Ehman, {Richard Lorne} and An, {Kai Nan}",
year = "2003",
month = "7",
doi = "10.1016/S0268-0033(03)00070-6",
language = "English (US)",
volume = "18",
pages = "537--542",
journal = "Clinical Biomechanics",
issn = "0268-0033",
publisher = "Elsevier Limited",
number = "6",

}

TY - JOUR

T1 - Measurement of muscle activity with magnetic resonance elastography

AU - Heers, Guido

AU - Jenkyn, Thomas

AU - Alex Dresner, M.

AU - Klein, Marc Oliver

AU - Basford, Jeffrey R.

AU - Kaufman, Kenton R

AU - Ehman, Richard Lorne

AU - An, Kai Nan

PY - 2003/7

Y1 - 2003/7

N2 - Objective. To non-invasively determine muscle activity. Design. A correlation analysis study. Background. Electromyography is traditionally used to measure the electrical activity of a muscle and can be used to estimate muscle contraction intensity. This approach, however, is limited not only in terms of the volume of tissue that can be monitored, but must be invasive if deep lying muscles are studied. We wished to avoid these limitations and used magnetic resonance elastography in an attempt to non-invasively determine muscle activity. This novel approach uses a conventional MRI system. However, in addition to the imaging gradients, an oscillating, motion sensitizing field gradient is applied to detect mechanical waves that have been generated within the tissue. The wavelength correlates with the stiffness of the muscle and hence with the activity of the muscle. Methods. Six volunteers (mean age: 30.1 years, range: 27-36 years) without orthopedic or neuromuscular abnormalities, lay supine with their legs within the coil of a MRI scanner. The wavelengths of mechanically generated shear waves in the tibialis anterior, medial and lateral head of the gastrocnemius and the soleus were measured as the subjects resisted ankle plantar-flexing (8.2 and 16.4 nm) and dorsi-flexing (20.2 and 40.4 nm) moments. The findings were then compared to EMG data collected under the same loading conditions. Results. Magnetic resonance elastography wavelengths were linearly correlated to the muscular activity as defined by electromyography. (TA, R2=0.89, P=0.02; MG, R2=0.82, P=0.05; LG, R2=0.88, P=0.03; S, R2=0.90, P=0.02) Conclusions. Magnetic resonance elastography may be a promising tool for the non-invasive determination of muscle activity. Relevance. Magnetic resonance elastography has potential as the basis for a new non-invasive approach to study in vivo muscle function.

AB - Objective. To non-invasively determine muscle activity. Design. A correlation analysis study. Background. Electromyography is traditionally used to measure the electrical activity of a muscle and can be used to estimate muscle contraction intensity. This approach, however, is limited not only in terms of the volume of tissue that can be monitored, but must be invasive if deep lying muscles are studied. We wished to avoid these limitations and used magnetic resonance elastography in an attempt to non-invasively determine muscle activity. This novel approach uses a conventional MRI system. However, in addition to the imaging gradients, an oscillating, motion sensitizing field gradient is applied to detect mechanical waves that have been generated within the tissue. The wavelength correlates with the stiffness of the muscle and hence with the activity of the muscle. Methods. Six volunteers (mean age: 30.1 years, range: 27-36 years) without orthopedic or neuromuscular abnormalities, lay supine with their legs within the coil of a MRI scanner. The wavelengths of mechanically generated shear waves in the tibialis anterior, medial and lateral head of the gastrocnemius and the soleus were measured as the subjects resisted ankle plantar-flexing (8.2 and 16.4 nm) and dorsi-flexing (20.2 and 40.4 nm) moments. The findings were then compared to EMG data collected under the same loading conditions. Results. Magnetic resonance elastography wavelengths were linearly correlated to the muscular activity as defined by electromyography. (TA, R2=0.89, P=0.02; MG, R2=0.82, P=0.05; LG, R2=0.88, P=0.03; S, R2=0.90, P=0.02) Conclusions. Magnetic resonance elastography may be a promising tool for the non-invasive determination of muscle activity. Relevance. Magnetic resonance elastography has potential as the basis for a new non-invasive approach to study in vivo muscle function.

KW - EMG

KW - Magnetic resonance elastography

KW - Material properties

KW - MRI

KW - Muscle

KW - Muscle contraction

KW - Strength

UR - http://www.scopus.com/inward/record.url?scp=0038048448&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0038048448&partnerID=8YFLogxK

U2 - 10.1016/S0268-0033(03)00070-6

DO - 10.1016/S0268-0033(03)00070-6

M3 - Article

C2 - 12828903

AN - SCOPUS:0038048448

VL - 18

SP - 537

EP - 542

JO - Clinical Biomechanics

JF - Clinical Biomechanics

SN - 0268-0033

IS - 6

ER -