Measurement of coronary blood flow and flow reserve using magnetic resonance imaging

Thomas M. Grist, Jason A. Polzin, Jesus A. Bianco, Thomas K F Foo, Matthew A Bernstein, Charles M. Mistretta

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Purpose: It was the purpose of this study to demonstrate the feasibility of performing coronary artery flow and coronary flow reserve (CFR) measurements in normal human volunteers using a magnetic resonance (MR) phase contrast technique. Materials and Methods: Coronary flow rate, flow velocity, peak flow and CFR were determined at rest and during pharmacologically induced hyperemia in 10 healthy volunteers. The flow measurements were obtained during a single breath-hold by using a fast, prospectively gated, segmented k-space gradient-echo phase contrast acquisition with view sharing (FAST-CARD PC) that was modified to improve sampling of the diastolic flow. Data were processed using the standard phase difference (PD) processing techniques as well as a new complex difference (CD) flow measurement method intended to improve the accuracy of flow measurements in small vessels. Results: Mean hyperemic flow velocity (40 ± 16 cm/s) and blood flow (3.9 ± 1.5 ml/s) rates differed significantly from resting velocity (13 ± 6.6 cm/s) and flow (1.1 ± 0.4 ml/s) measurements (p < 0.0001). PD methods consistently measured larger flow rates at rest (24% larger, p < 0.0005) and stress (29% larger, p < 0.0001). CFR, calculated as the ratio of the mean PD flows (4.7 ± 2.8), was higher than CFR calculated as the ratio of mean CD flows (4.2 ± 1.8); however, the differences did not reach statistical significance (p = 0.07). Flow measurements performed in adjacent slices of the same vessel correlated well (r = 0.88). Conclusions: Coronary flow and CFR measurements using the MR techniques are feasible and are similar to those reported in the literature for healthy volunteers.

Original languageEnglish (US)
Pages (from-to)80-89
Number of pages10
JournalCardiology
Volume88
Issue number1
StatePublished - 1997
Externally publishedYes

Fingerprint

Healthy Volunteers
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Hyperemia
Coronary Vessels

Keywords

  • Coronary blood flow
  • Magnetic resonance

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Grist, T. M., Polzin, J. A., Bianco, J. A., Foo, T. K. F., Bernstein, M. A., & Mistretta, C. M. (1997). Measurement of coronary blood flow and flow reserve using magnetic resonance imaging. Cardiology, 88(1), 80-89.

Measurement of coronary blood flow and flow reserve using magnetic resonance imaging. / Grist, Thomas M.; Polzin, Jason A.; Bianco, Jesus A.; Foo, Thomas K F; Bernstein, Matthew A; Mistretta, Charles M.

In: Cardiology, Vol. 88, No. 1, 1997, p. 80-89.

Research output: Contribution to journalArticle

Grist, TM, Polzin, JA, Bianco, JA, Foo, TKF, Bernstein, MA & Mistretta, CM 1997, 'Measurement of coronary blood flow and flow reserve using magnetic resonance imaging', Cardiology, vol. 88, no. 1, pp. 80-89.
Grist TM, Polzin JA, Bianco JA, Foo TKF, Bernstein MA, Mistretta CM. Measurement of coronary blood flow and flow reserve using magnetic resonance imaging. Cardiology. 1997;88(1):80-89.
Grist, Thomas M. ; Polzin, Jason A. ; Bianco, Jesus A. ; Foo, Thomas K F ; Bernstein, Matthew A ; Mistretta, Charles M. / Measurement of coronary blood flow and flow reserve using magnetic resonance imaging. In: Cardiology. 1997 ; Vol. 88, No. 1. pp. 80-89.
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