Maturation of intracranial immature teratomas: Report of two cases

Mark E. Shaffrey, Giuseppe Lanzino, Beatriz S. Lopes, Richard B. Hessler, Neal F. Kassell, Scott R. VandenBerg

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Immature teratomas arising within the central neuraxis are rare neoplasms. These tumors contain diverse cell lineages that retain an embryonal character and display phenotype differentiation attributed to the three classic germ layers. The clinical management of these lesions is unclear, due in part to their low incidence and to an incomplete understanding of their natural history. Although the potential for phenotypic differentiation and cellular maturation within immature teratomas arising in the gonads is well documented, this has not been described in the intracranial tumors. In the present report, the authors describe two cases of intracranial immature teratomas, one involving the pineal region and the other involving the left frontotemporal lobes, which underwent cellular differentiation and maturation. At initial resection, the tumors from both cases were composed predominantly of primitive neuroepithelial tissue that was admixed with immature and differentiating mesenchymal and epithelial structures. No foci of germinoma, endodermal sinus, choriocarcinoma, or embryonal carcinoma tissue were present. Subsequent resections in both cases revealed an absence of immature tissue. The tumor in Case 1 contained only differentiated epithelial and mesenchymal tissue with no neuroepithelial component, whereas the tumor in Case 2 demonstrated abundant mature neuronal and glial tissue. These two cases from different intracranial sites suggest that spontaneous maturation may be a significant aspect of the natural history of intracranial immature teratomas.

Original languageEnglish (US)
Pages (from-to)672-676
Number of pages5
JournalJournal of Neurosurgery
Volume85
Issue number4
StatePublished - Oct 1996
Externally publishedYes

Fingerprint

Teratoma
Neoplasms
Germinoma
Embryonal Carcinoma
Germ Layers
Choriocarcinoma
Gonads
Cell Lineage
Natural History
Neuroglia
Epithelium
Phenotype
Incidence

Keywords

  • chemotherapy
  • intracranial neoplasm
  • prognosis
  • teratoma

ASJC Scopus subject areas

  • Surgery
  • Medicine(all)
  • Clinical Neurology

Cite this

Shaffrey, M. E., Lanzino, G., Lopes, B. S., Hessler, R. B., Kassell, N. F., & VandenBerg, S. R. (1996). Maturation of intracranial immature teratomas: Report of two cases. Journal of Neurosurgery, 85(4), 672-676.

Maturation of intracranial immature teratomas : Report of two cases. / Shaffrey, Mark E.; Lanzino, Giuseppe; Lopes, Beatriz S.; Hessler, Richard B.; Kassell, Neal F.; VandenBerg, Scott R.

In: Journal of Neurosurgery, Vol. 85, No. 4, 10.1996, p. 672-676.

Research output: Contribution to journalArticle

Shaffrey, ME, Lanzino, G, Lopes, BS, Hessler, RB, Kassell, NF & VandenBerg, SR 1996, 'Maturation of intracranial immature teratomas: Report of two cases', Journal of Neurosurgery, vol. 85, no. 4, pp. 672-676.
Shaffrey ME, Lanzino G, Lopes BS, Hessler RB, Kassell NF, VandenBerg SR. Maturation of intracranial immature teratomas: Report of two cases. Journal of Neurosurgery. 1996 Oct;85(4):672-676.
Shaffrey, Mark E. ; Lanzino, Giuseppe ; Lopes, Beatriz S. ; Hessler, Richard B. ; Kassell, Neal F. ; VandenBerg, Scott R. / Maturation of intracranial immature teratomas : Report of two cases. In: Journal of Neurosurgery. 1996 ; Vol. 85, No. 4. pp. 672-676.
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