Mapping antigens of membranous nephropathy: almost there

Sanjeev Sethi; Benjamin Madden

doi:10.1016/j.kint.2023.01.003

Mapping antigens of membranous nephropathy: almost there

Sanjeev Sethi, Benjamin Madden

Laboratory Medicine and Pathology

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

Membranous nephropathy (MN) is characterized by subepithelial accumulation of immune complexes along the glomerular basement membranes. The immune complexes compromise IgG and the corresponding target antigen. Recent advances have led to the discovery of novel target MN antigens. In this study, by Caza et al., 7 novel “putative” antigens are proposed. Target antigens can now be identified in approximately 90% of cases of MN. In addition to describing another 10 novel putative antigens, we propose a working algorithm for evaluating the target antigens in MN.

Original language	English (US)
Pages (from-to)	469-472
Number of pages	4
Journal	Kidney international
Volume	103
Issue number	3
DOIs	https://doi.org/10.1016/j.kint.2023.01.003
State	Published - Mar 2023

ASJC Scopus subject areas

Nephrology

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10.1016/j.kint.2023.01.003

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title = "Mapping antigens of membranous nephropathy: almost there",

abstract = "Membranous nephropathy (MN) is characterized by subepithelial accumulation of immune complexes along the glomerular basement membranes. The immune complexes compromise IgG and the corresponding target antigen. Recent advances have led to the discovery of novel target MN antigens. In this study, by Caza et al., 7 novel “putative” antigens are proposed. Target antigens can now be identified in approximately 90% of cases of MN. In addition to describing another 10 novel putative antigens, we propose a working algorithm for evaluating the target antigens in MN.",

author = "Sanjeev Sethi and Benjamin Madden",

note = "Publisher Copyright: {\textcopyright} 2023 International Society of Nephrology",

year = "2023",

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doi = "10.1016/j.kint.2023.01.003",

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T2 - almost there

AU - Sethi, Sanjeev

AU - Madden, Benjamin

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N2 - Membranous nephropathy (MN) is characterized by subepithelial accumulation of immune complexes along the glomerular basement membranes. The immune complexes compromise IgG and the corresponding target antigen. Recent advances have led to the discovery of novel target MN antigens. In this study, by Caza et al., 7 novel “putative” antigens are proposed. Target antigens can now be identified in approximately 90% of cases of MN. In addition to describing another 10 novel putative antigens, we propose a working algorithm for evaluating the target antigens in MN.

AB - Membranous nephropathy (MN) is characterized by subepithelial accumulation of immune complexes along the glomerular basement membranes. The immune complexes compromise IgG and the corresponding target antigen. Recent advances have led to the discovery of novel target MN antigens. In this study, by Caza et al., 7 novel “putative” antigens are proposed. Target antigens can now be identified in approximately 90% of cases of MN. In addition to describing another 10 novel putative antigens, we propose a working algorithm for evaluating the target antigens in MN.

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DO - 10.1016/j.kint.2023.01.003

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VL - 103

SP - 469

EP - 472

JO - Kidney international

JF - Kidney international

IS - 3

ER -

Mapping antigens of membranous nephropathy: almost there

Abstract

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