TY - JOUR
T1 - Management of Mild Hypertension
AU - TEXTOR, STEPHEN C.
N1 - Funding Information:
Medical Research Council Trial of Treatment of Mild Hypertension.
Funding Information:
A study of mild hypertension conducted by the Medical Research Council 16 represents one of the largest multicenter longitudinal follow-up projects reported, with 17,354 subjects under surveillance in a general practice setting for 5 years. It confirmed the additive risks of smoking and hypertension previously reported. 1 Moreover, it added a comparison among placebo control, β-adrenergic blocker-based therapy, and diuretic-based therapy in the mildly hypertensive range. Again, the incidence of stroke was considerably diminished, more so in the group receiving diuretics (67%) than in the group receiving β-adrenergic blockers (24%). A diminution of coronary artery events was evident only in a subgroup of non-smokers who received propranolol. Overall, however, no decrease in cardiovascular or coronary artery events or total mortality was noted in this trial. Of interest, no adverse effects of diuretics were detected in this sizable population during a prolonged follow-up period.
PY - 1989
Y1 - 1989
N2 - The benefits of blood pressure reduction have been clearly established for diastolic pressures of more than 100 mm Hg. For patients with a diastolic pressure between 90 and 99 mm Hg on repeated measurements, treatment should be initiated if other risk factors are present—for example, a family history of coronary risk, increased cholesterol level, male sex, smoking, or diabetes mellitus. When the pressure seems to be labile or exaggerated in the office, home or ambulatory readings may provide confirmatory information. For persons with diastolic pressures in the range of 90 to 94 mm Hg, it may be suitable to initiate therapy with nonpharmacologic maneuvers such as sodium restriction, weight reduction, and physical conditioning. In such cases, careful follow-up of blood pressure is particularly important because it may increase later. The initial therapy for mild hypertension should be selected to minimize adverse effects and should be tailored to the individual patient. Management of all levels of hypertension must be considered in light of the associated risk factors and a concomitant effort to minimize cardiovascular risk.
AB - The benefits of blood pressure reduction have been clearly established for diastolic pressures of more than 100 mm Hg. For patients with a diastolic pressure between 90 and 99 mm Hg on repeated measurements, treatment should be initiated if other risk factors are present—for example, a family history of coronary risk, increased cholesterol level, male sex, smoking, or diabetes mellitus. When the pressure seems to be labile or exaggerated in the office, home or ambulatory readings may provide confirmatory information. For persons with diastolic pressures in the range of 90 to 94 mm Hg, it may be suitable to initiate therapy with nonpharmacologic maneuvers such as sodium restriction, weight reduction, and physical conditioning. In such cases, careful follow-up of blood pressure is particularly important because it may increase later. The initial therapy for mild hypertension should be selected to minimize adverse effects and should be tailored to the individual patient. Management of all levels of hypertension must be considered in light of the associated risk factors and a concomitant effort to minimize cardiovascular risk.
UR - http://www.scopus.com/inward/record.url?scp=0024792658&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024792658&partnerID=8YFLogxK
U2 - 10.1016/S0025-6196(12)65710-3
DO - 10.1016/S0025-6196(12)65710-3
M3 - Article
C2 - 2601413
AN - SCOPUS:0024792658
SN - 0025-6196
VL - 64
SP - 1543
EP - 1552
JO - Mayo Clinic Proceedings
JF - Mayo Clinic Proceedings
IS - 12
ER -